A hypothesis for an embryonic origin of pluripotent Oct-4+ stem cells in adult bone marrow and other tissues

被引：164

作者：

Ratajczak, M. Z.

Machalinski, B.

Wojakowski, W.

Ratajczak, J.

Kucia, M.

机构：

[1] Univ Louisville, Chair Canc Biol, Stem Cell Biol Program, James Graham Brown Canc Ctr, Louisville, KY 40202 USA

[2] Pomeranian Med Univ, Dept Physiol, Szczecin, Poland

[3] Med Univ Silesia, Dept Cardiol 3, Katowice, Poland

来源：

LEUKEMIA | 2007年 / 21卷 / 05期

关键词：

Oct-4; Nanog; SSEA-4; VSELs; embryonic stem cells;

D O I：

10.1038/sj.leu.2404630

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Accumulating evidence demonstrates that adult tissues contain a population of stem cells that express early developmental markers such as stage-specific embryonic antigen and transcription factors Oct-4 and Nanog. These are the markers characteristic for embryonic stem cells, epiblast stem cells and primordial germ cells. The presence of these stem cells in adult tissues including bone marrow, epidermis, bronchial epithelium, myocardium, pancreas and testes supports the concept that adult tissues contain some population of pluripotent stem cells that is deposited in embryogenesis during early gastrulation. In this review we will discuss these data and present a hypothesis that these cells could be direct descendants of the germ lineage. The germ lineage in order to pass genes on to the next generations creates soma and thus becomes a 'mother lineage' for all somatic cell lineages present in the adult body.

引用

页码：860 / 867

页数：8

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