p53 single nucleotide polymorphisms and bladder cancer

被引:0
作者
Biros, E [1 ]
Kalina, I
Salagovic, J
Habalová, V
Hrivnák, M
Valansky, L
机构
[1] Safarik Univ, Sch Med, Dept Med Biol, Kosice 04066, Slovakia
[2] Teaching Hosp, Dept Urol, Kosice, Slovakia
关键词
bladder cancer; cancer susceptibility; p53; germ line polymorphism;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Two p53 germline polymorphisms, a BstUI in exon 4 and a MspI in intron 6 were studied using polymerase chain reaction (PCR) based methods in 50 patients with bladder cancer and 145 healthy controls. Increased frequencies of the BstUI and MspI A2 alleles were found to be associated with statistically non-significant (p = 0.2308 and p = 0.5959) but increased odd ratios for bladder cancel (OR 1.44, 95% CI 0.82-2.27 and OR 1.20, 95% CI 0.61-2.33). Statistically significant difference between patients with bladder cancer and controls was found in the distribution of MspI genotypes. There was a significantly lower proportion of the heterozygous A1A2 genotype in all patients but not in controls (p = 0.0354). The results of this study suggest that BstUI and MspI germline polymorphisms of the tumor suppressor gene p53 marginally modify the risk of bladder cancer.
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页码:303 / 306
页数:4
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