Interleukin-28B dampens airway inflammation through up-regulation of natural killer cell-derived IFN-γ

被引：14
作者：
Yan, Bailing [1 ]
Chen, Feng [2 ]
Xu, Lijun [3 ]
Wang, Yanshi [4 ]
Wang, Xuefu [4 ,5 ]
机构：
[1] Jilin Univ, Dept Emergency, Hosp 1, Changchun 130021, Peoples R China
[2] Jilin Univ, Dermatol Dept, China Japan Union Hosp, Changchun 130033, Peoples R China
[3] Jilin Univ, Hosp 1, Dept Resp Med, Changchun 130021, Peoples R China
[4] Univ Sci & Technol China, Sch Life Sci, Inst Immunol, Hefei 230027, Anhui, Peoples R China
[5] Anhui Med Univ, Sch Pharmacol, Hefei 230032, Anhui, Peoples R China
来源：
SCIENTIFIC REPORTS | 2017年 / 7卷
关键词：
NK CELLS; INTERFERON-LAMBDA; DENDRITIC CELLS; ASTHMA; EXPRESSION; TH1;
D O I：
10.1038/s41598-017-03856-w
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Interleukin-28A (IL-28A) modulates CD11c+ dendritic cell (DC) function and promotes type 1T helper (Th1) differentiation, thus suppressing allergic airway diseases. However, the function of the IL-28A isoform IL-28B in these diseases remains largely unknown. In this study, we revealed a novel role of IL-28B in inducing type 1 immunity and protecting against ovalbumin (OVA)-induced allergic asthma in mice. IL-28B overexpression in wild-type mice promoted natural killer (NK) cell polarization in the lung, leading to the increased number of interferon (IFN)-gamma-producing NK1 cells as well as Th1 differentiation. Importantly, IL-28B overexpression had no protective effect on OVA-induced asthma in IFN-gamma-knockout (IFN-gamma-/-) mice. These results demonstrate that IL-28B ameliorates experimental allergic asthma via
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页数：8
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