Cutaneous and Gastrointestinal Leukocytoclastic Vasculitis Induced by Palbociclib in a Metastatic Breast Cancer Patient: A Case Report

被引：9
作者：
Guillemois, Sylvere [1 ]
Patsouris, Anne [1 ]
Peyraga, Guillaume [2 ]
Chassain, Kevin [3 ]
Le Corre, Yannick [3 ]
Campone, Mario [1 ]
Augereau, Paule [1 ]
机构：
[1] Ctr Paul Papin, Med Oncol Dept, Inst Cancerol Ouest, Angers, France
[2] Ctr Paul Papin, Radiat Therapy Dept, Inst Cancerol Ouest, Angers, France
[3] Univ Hosp Angers, Dermatol Dept, Angers, France
来源：
CLINICAL BREAST CANCER | 2018年 / 18卷 / 05期
关键词：
Cyclin-dependent kinase 4/6 inhibitor; Drug-induced vasculitis; Faslodex; Fulvestrant; Ibrance; Vasculitis treatment; RANDOMIZED CONTROLLED-TRIAL; THERAPY; LETROZOLE;
D O I：
10.1016/j.clbc.2018.07.006
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The efficacy and safety of palbociclib, a cyclindependent kinase 4/6 inhibitor, used in combination with fulvestrant was assessed in women with advanced breast cancer (ABC) whose disease had progressed during previous endocrine therapy, with a significant improvement of progression-free survival and good health-related quality of life. We report a case of an 80-year-old patient with ABC who presented a cutaneous and gastrointestinal vasculitis during treatment with palbociclib and fulvestrant. The skin biopsy was consistent with a leukocytoclastic vasculitis with immunoglobulin A deposits in dermal blood vessels. The symptoms disappeared with the arrest of palbociclib and fulvestrant treatment and a high dose corticotherapy. (C) 2018 Elsevier Inc. All rights reserved.
引用
收藏
页码：E755 / E758
页数：4
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