Pyridoxal-5-phosphate plasma concentrations in children receiving tuberculosis chemotherapy including isoniazid

被引：24

作者：

Cilliers, K. ^{[3
]}

Labadarios, D. ^{[4
]}

Schaaf, H. S. ^{[1
,2
]}

Willemse, M. ^{[1
,2
]}

Maritz, J. S. ^{[5
]}

Werely, C. J. ^{[6
,7
]}

Hussey, G. ^{[8
]}

Donald, P. R. ^{[1
,2
,6
,7
]}

机构：

[1] Univ Stellenbosch, Dept Paediat & Child Hlth, Fac Hlth Sci, ZA-7505 Tygerberg, South Africa

[2] Tygerberg Childrens Hosp, Tygerberg, South Africa

[3] Univ Stellenbosch, Fac Hlth Sci, Dept Human Nutr, ZA-7505 Tygerberg, South Africa

[4] Human Sci Res Council, Cape Town, South Africa

[5] S African MRC, Biostat Unit, Cape Town, South Africa

[6] Univ Stellenbosch, Div Human Genet & Mol Biol, Fac Hlth Sci, DST NRF Ctr Excellence Biomed TB Res, ZA-7505 Tygerberg, South Africa

[7] Univ Stellenbosch, MRC Ctr Mol & Cellular Biol, Fac Hlth Sci, DST NRF Ctr Excellence Biomed TB Res, ZA-7505 Tygerberg, South Africa

[8] Univ Cape Town, Inst Infect Dis & Mol Med, ZA-7701 Rondebosch, South Africa

来源：

ACTA PAEDIATRICA | 2010年 / 99卷 / 05期

基金：

新加坡国家研究基金会;

关键词：

Childhood; HIV; Isoniazid; Pyridoxine; Tuberculosis; C-REACTIVE PROTEIN; PYRIDOXINE SUPPLEMENTATION; VITAMIN-B6; SUPPLEMENTATION; THERAPY; DEFICIENCY; INFECTION;

D O I：

10.1111/j.1651-2227.2010.01696.x

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Aim: Little is known about pyridoxine nutriture of children treated with isoniazid (INH) regimens. This study documents plasma pyridoxal 5'-phosphate (PLP) concentrations in children, HIV-infected and HIV-uninfected, receiving INH regimens. Methods: Children from the Western Cape of South Africa hospitalized for tuberculosis (TB) management were studied. Plasma PLP concentrations were determined on enrolment, 1-month after commencing TB treatment, and again after 4-month's treatment. The children received a supplement meeting pyridoxine requirements. Results: Nineteen HIV-infected and 33 HIV-uninfected children received INH (dosage range 4-20 mg/kg) daily. Mean PLP plasma concentrations on enrolment were 8.32 (SD 6.75) ng/mL and 11.28 (SD 3.02) ng/mL in HIV-infected and HIV-uninfected children, respectively (p = 0.11) and after 4-month's treatment 6.75 (SD 2.71) ng/mL and 14.76 (SD 7.96) ng/mL (p < 0.001). On enrolment 9 (50%) HIV-infected and 5 (15%) HIV-uninfected children (p = 0.016) had suboptimal PLP concentrations (< 6 ng/mL); after 4-month's treatment 8 (42%) and 2 (6%) (p = 0.004). Conclusion: Plasma PLP concentrations in children treated for TB were low on enrolment in HIV-infected and HIV-uninfected children; after 4-month's treatment low values were still common in HIV-infected children. Additional pyridoxine supplementation of malnourished children treated for tuberculosis is advisable, particularly those HIV-infected.

引用

页码：705 / 710

页数：6

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