How I treat hemochromatosis

被引：134
作者：
Adams, Paul C. [1 ]
Barton, James C. [2 ,3 ]
机构：
[1] Univ Western Ontario, Univ Hosp, London, ON N6A 5A5, Canada
[2] So Iron Disorders Ctr, Birmingham, AL USA
[3] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA
来源：
BLOOD | 2010年 / 116卷 / 03期
关键词：
INTESTINAL IRON-ABSORPTION; HFE C282Y HOMOZYGOTES; LONG-TERM SURVIVAL; HEREDITARY HEMOCHROMATOSIS; NATURAL-HISTORY; SERUM FERRITIN; GENETIC HEMOCHROMATOSIS; ALCOHOL-CONSUMPTION; PHLEBOTOMY THERAPY; BLOOD-DONATION;
D O I：
10.1182/blood-2010-01-261875
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Hemochromatosis is a common genetic disorder in which iron may progressively accumulate in the liver, heart, and other organs. The primary goal of therapy is iron depletion to normalize body iron stores and to prevent or decrease organ dysfunction. The primary therapy to normalize iron stores is phlebotomy. In this opinion article, we discuss the indications for and monitoring of phlebotomy therapy to achieve iron depletion, maintenance therapy, dietary and pharmacologic maneuvers that could reduce iron absorption, and the role of voluntary blood donation. (Blood. 2010; 116(3): 317-325.
引用
收藏
页码：317 / 325
页数：9
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