Gene targeting in livestock: a preview

被引：33
作者：
Clark, AJ [1 ]
Burl, S [1 ]
Denning, C [1 ]
Dickinson, P [1 ]
机构：
[1] Roslin Inst, Roslin EH25 9PS, Midlothian, Scotland
来源：
TRANSGENIC RESEARCH | 2000年 / 9卷 / 4-5期
关键词：
biotechnology; gene targeting; livestock; nuclear transfer; somatic cells;
D O I：
10.1023/A:1008974616402
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Until recently genetically modified livestock could only be generated by pronuclear injection. The discovery that animals can be cloned by nuclear transfer from cultured somatic cells means that it will now be possible to achieve gene targeting in these species. We discuss current developments in NT, the prospects and technical challenges for introducing targeted changes into the germline by this route, and the types of application for which this new technology will be used.
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收藏
页码：263 / 275
页数：13
相关论文
共 100 条
[1]   TELOMERE LENGTH PREDICTS REPLICATIVE CAPACITY OF HUMAN FIBROBLASTS [J].
ALLSOPP, RC ;
VAZIRI, H ;
PATTERSON, C ;
GOLDSTEIN, S ;
YOUNGLAI, EV ;
FUTCHER, AB ;
GREIDER, CW ;
HARLEY, CB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (21) :10114-10118
[2]   Production of goats by somatic cell nuclear transfer [J].
Baguisi, A ;
Behboodi, E ;
Melican, DT ;
Pollock, JS ;
Destrempes, MM ;
Cammuso, C ;
Williams, JL ;
Nims, SD ;
Porter, CA ;
Midura, P ;
Palacios, MJ ;
Ayres, SL ;
Denniston, RS ;
Hayes, ML ;
Ziomek, CA ;
Meade, HM ;
Godke, RA ;
Gavin, WG ;
Overström, EW ;
Echelard, Y .
NATURE BIOTECHNOLOGY, 1999, 17 (05) :456-461
[3]   Extension of life-span by introduction of telomerase into normal human cells [J].
Bodnar, AG ;
Ouellette, M ;
Frolkis, M ;
Holt, SE ;
Chiu, CP ;
Morin, GB ;
Harley, CB ;
Shay, JW ;
Lichtsteiner, S ;
Wright, WE .
SCIENCE, 1998, 279 (5349) :349-352
[4]  
BRIGGS ROBERT, 1957, J MORPH, V100, P269, DOI 10.1002/jmor.1051000204
[5]   Single-copy transgenic mice with chosen-site integration [J].
Bronson, SK ;
Plaehn, EG ;
Kluckman, KD ;
Hagaman, JR ;
Maeda, N ;
Smithies, O .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (17) :9067-9072
[6]   Bypass of senescence after disruption of p21(CIP1/WAF1) gene in normal diploid human fibroblasts [J].
Brown, JP ;
Wei, WY ;
Sedivy, JM .
SCIENCE, 1997, 277 (5327) :831-834
[7]   Improved properties of FLP recombinase evolved by cycling mutagenesis [J].
Buchholz, F ;
Angrand, PO ;
Stewart, AF .
NATURE BIOTECHNOLOGY, 1998, 16 (07) :657-662
[8]   NORMAL DEVELOPMENT AND BEHAVIOR OF MICE LACKING THE NEURONAL CELL-SURFACE PRP PROTEIN [J].
BUELER, H ;
FISCHER, M ;
LANG, Y ;
BLUETHMANN, H ;
LIPP, HP ;
DEARMOND, SJ ;
PRUSINER, SB ;
AGUET, M ;
WEISSMANN, C .
NATURE, 1992, 356 (6370) :577-582
[9]   Requirement for p53 and p21 to sustain G2 arrest after DNA damage [J].
Bunz, F ;
Dutriaux, A ;
Lengauer, C ;
Waldman, T ;
Zhou, S ;
Brown, JP ;
Sedivy, JM ;
Kinzler, KW ;
Vogelstein, B .
SCIENCE, 1998, 282 (5393) :1497-1501
[10]   Sheep cloned by nuclear transfer from a cultured cell line [J].
Campbell, KHS ;
McWhir, J ;
Ritchie, WA ;
Wilmut, I .
NATURE, 1996, 380 (6569) :64-66
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