α-amino esters as nucleophiles in diastereoselective palladium catalysed allylic substitution reactions

被引：21

作者：

Humphries, ME

Clark, BP

Williams, JMJ

机构：

[1] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England

[2] Eli Lilly & Co, Lilly Res Ctr Ltd, Windlesham GU20 6PH, Surrey, England

来源：

TETRAHEDRON-ASYMMETRY | 1998年 / 9卷 / 05期

关键词：

D O I：

10.1016/S0957-4166(98)00060-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Allylic acetates undergo palladium catalysed allylic substitution with amino ester nucleophiles. Using enantiomerically pure cx-amino esters, the substitution products are obtained with moderate diastereoselectivity (up to 85: 15: 70% d.e.). The reactions could also be performed using an enantiomerically pure ligand, which was found to exert a stronger influence over the stereochemical outcome. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：749 / 751

页数：3

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