Genome-wide linkage analysis of type 2 diabetes mellitus reconfirms the susceptibility locus on 11p13-p12 in Japanese

被引：20

作者：

Nawata, H

Shirasawa, S

Nakashima, N

Araki, E

Hashiguchi, J

Miyake, S

Yamauchi, T

Hamaguchi, K

Yoshimatsu, H

Takeda, H

Fukushima, H

Sasahara, T

Yamaguchi, K

Sonoda, N

Sonoda, T

Matsumoto, M

Tanaka, Y

Sugimoto, H

Tsubouchi, H

Inoguchi, T

Yanase, T

Wake, N

Narazaki, K

Eto, T

Umeda, F

Nakazaki, M

Ono, J

Asano, T

Ito, Y

Akazawa, S

Hazegawa, I

Takasu, N

Shinohara, M

Nishikawa, T

Nagafuchi, S

Okeda, T

Eguchi, K

Iwase, M

Ishikawa, M

Aoki, M

Keicho, N

Kato, N

Yasuda, K

Yamamoto, K

Sasazuki, T

机构：

[1] Int Med Ctr Japan, Res Inst, Dept Pathol, Shinjuku Ku, Tokyo 1628655, Japan

[2] Kyushu Univ, Grad Sch Med Sci, Dept Med & Bioregulatory Sci, Fukuoka 812, Japan

[3] Kyushu Univ Hosp, Dept Med Informat, Fukuoka 812, Japan

[4] Kumamoto Univ, Fac Med & Pharmaceut Sci, Dept Metab Med, Kumamoto, Japan

[5] Tenposan Clin, Kagoshima, Japan

[6] Sasebo Cent Hosp, Nagasaki, Japan

[7] Yukuhashi Cent Hosp, Fukuoka, Japan

[8] Oita Univ, Fac Med, Dept Internal Med 1, Oita 87011, Japan

[9] Yatsushiro Gen Hosp, Kumamoto, Japan

[10] Publ Tamana Cent Hosp, Kumamoto, Japan

[11] Omuta Tenryo Hosp, Fukuoka, Japan

[12] Oita Prefectural Hosp, Oita, Japan

[13] Sonoda Clin, Kagoshima, Japan

[14] Kitakyushu Municipal Med Ctr, Fukuoka, Japan

[15] Univ Occupat & Environm Hlth, Sch Med, Dept Internal Med 1, Fukuoka, Japan

[16] Sugimoto Clin, Fukuoka, Japan

[17] Natl Hlth Insurance Takachiho Town Hosp, Miyazaki, Japan

[18] Narazaki Clin, Fukuoka, Japan

[19] Fukuoka Med Assoc Hosp, Diabetol & Endocrinol Div Internal Med, Fukuoka, Japan

[20] Kagoshima Univ, Grad Sch Med, Dept Cardiovasc Resp & Metab Med, Kagoshima 890, Japan

[21] Fukuoka Univ, Sch Med, Dept Lab Med, Fukuoka 81401, Japan

[22] Fukuoka Univ, Sch Med, Dept Internal Med 1, Fukuoka 81401, Japan

[23] Furugou Clin, Oita, Japan

[24] Shin Koga Hosp, Fukuoka, Japan

[25] Kamiamakusa Gen Hosp, Kumamoto, Japan

[26] Univ Ryukyus, Fac Med, Dept Endocrinol & Metab, Okinawa, Japan

[27] Natl Hlth Insurance Matsubase Town Hosp, Kumamoto, Japan

[28] Kyushu Univ, Grad Sch Med Sci, Dept Med & Biosystem Sci, Fukuoka 812, Japan

[29] Shin Kokura Hosp, Fukuoka, Japan

[30] Nagasaki Univ, Grad Sch Biomed Sci, Dept Internal Med 1, Nagasaki 852, Japan

[31] Kyushu Univ, Grad Sch Med Sci, Dept Med & Clin Sci, Fukuoka 812, Japan

[32] Kyushu Univ, Med Inst Bioregulat, Fukuoka 812, Japan

来源：

JOURNAL OF HUMAN GENETICS | 2004年 / 49卷 / 11期

关键词：

Type 2 diabetes mellitus; Japanese; affected sib-pairs; linkage; chromosome; 11p;

D O I：

10.1007/s10038-004-0199-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Type 2 diabetes mellitus is a heterogeneous disorder, and the development of type 2 diabetes mellitus is associated with both insulin secretion defect and insulin resistance. The primary metabolic defect leading to type 2 diabetes mellitus has been thought to be varied among populations, especially in Japanese and Caucasians. Here, we have done the genome-wide scan for type 2 diabetes mellitus using 102 affected Japanese sib-pairs to identify the genetic factors predisposing to type 2 diabetes mellitus. Nonparametric linkage analysis showed one suggestive evidence for linkage to 11p13-p12 [D11S905: two-point maximum LOD score (MLS) of 2.89 and multipoint MLS of 2.32] and one nominally significant evidence for linkage to 6q15-q16 (D6S462: two-point MLS of 2.02). Interestingly, the 11p13-p12 region was reported to be a susceptibility locus for Japanese type 2 diabetes mellitus with suggestive evidence of linkage, and D11S905 was within 5 cM to D11S935 with the highest MLS in the previous linkage analysis reported. The only overlapped susceptibility region with suggestive evidence of linkage for Japanese type 2 diabetes mellitus was D11S935 D11S905 among the three reports including this study. These results taken together suggest that a susceptibility gene for type 2 diabetes mellitus in Japanese will reside in 11p13-p12.

引用

页码：629 / 634

页数：6

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