Genome-wide linkage analysis of type 2 diabetes mellitus reconfirms the susceptibility locus on 11p13-p12 in Japanese

被引：20

作者：

Nawata, H

Shirasawa, S

Nakashima, N

Araki, E

Hashiguchi, J

Miyake, S

Yamauchi, T

Hamaguchi, K

Yoshimatsu, H

Takeda, H

Fukushima, H

Sasahara, T

Yamaguchi, K

Sonoda, N

Sonoda, T

Matsumoto, M

Tanaka, Y

Sugimoto, H

Tsubouchi, H

Inoguchi, T

Yanase, T

Wake, N

Narazaki, K

Eto, T

Umeda, F

Nakazaki, M

Ono, J

Asano, T

Ito, Y

Akazawa, S

Hazegawa, I

Takasu, N

Shinohara, M

Nishikawa, T

Nagafuchi, S

Okeda, T

Eguchi, K

Iwase, M

Ishikawa, M

Aoki, M

Keicho, N

Kato, N

Yasuda, K

Yamamoto, K

Sasazuki, T

机构：

[1] Int Med Ctr Japan, Res Inst, Dept Pathol, Shinjuku Ku, Tokyo 1628655, Japan

[2] Kyushu Univ, Grad Sch Med Sci, Dept Med & Bioregulatory Sci, Fukuoka 812, Japan

[3] Kyushu Univ Hosp, Dept Med Informat, Fukuoka 812, Japan

[4] Kumamoto Univ, Fac Med & Pharmaceut Sci, Dept Metab Med, Kumamoto, Japan

[5] Tenposan Clin, Kagoshima, Japan

[6] Sasebo Cent Hosp, Nagasaki, Japan

[7] Yukuhashi Cent Hosp, Fukuoka, Japan

[8] Oita Univ, Fac Med, Dept Internal Med 1, Oita 87011, Japan

[9] Yatsushiro Gen Hosp, Kumamoto, Japan

[10] Publ Tamana Cent Hosp, Kumamoto, Japan

[11] Omuta Tenryo Hosp, Fukuoka, Japan

[12] Oita Prefectural Hosp, Oita, Japan

[13] Sonoda Clin, Kagoshima, Japan

[14] Kitakyushu Municipal Med Ctr, Fukuoka, Japan

[15] Univ Occupat & Environm Hlth, Sch Med, Dept Internal Med 1, Fukuoka, Japan

[16] Sugimoto Clin, Fukuoka, Japan

[17] Natl Hlth Insurance Takachiho Town Hosp, Miyazaki, Japan

[18] Narazaki Clin, Fukuoka, Japan

[19] Fukuoka Med Assoc Hosp, Diabetol & Endocrinol Div Internal Med, Fukuoka, Japan

[20] Kagoshima Univ, Grad Sch Med, Dept Cardiovasc Resp & Metab Med, Kagoshima 890, Japan

[21] Fukuoka Univ, Sch Med, Dept Lab Med, Fukuoka 81401, Japan

[22] Fukuoka Univ, Sch Med, Dept Internal Med 1, Fukuoka 81401, Japan

[23] Furugou Clin, Oita, Japan

[24] Shin Koga Hosp, Fukuoka, Japan

[25] Kamiamakusa Gen Hosp, Kumamoto, Japan

[26] Univ Ryukyus, Fac Med, Dept Endocrinol & Metab, Okinawa, Japan

[27] Natl Hlth Insurance Matsubase Town Hosp, Kumamoto, Japan

[28] Kyushu Univ, Grad Sch Med Sci, Dept Med & Biosystem Sci, Fukuoka 812, Japan

[29] Shin Kokura Hosp, Fukuoka, Japan

[30] Nagasaki Univ, Grad Sch Biomed Sci, Dept Internal Med 1, Nagasaki 852, Japan

[31] Kyushu Univ, Grad Sch Med Sci, Dept Med & Clin Sci, Fukuoka 812, Japan

[32] Kyushu Univ, Med Inst Bioregulat, Fukuoka 812, Japan

来源：

JOURNAL OF HUMAN GENETICS | 2004年 / 49卷 / 11期

关键词：

Type 2 diabetes mellitus; Japanese; affected sib-pairs; linkage; chromosome; 11p;

D O I：

10.1007/s10038-004-0199-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Type 2 diabetes mellitus is a heterogeneous disorder, and the development of type 2 diabetes mellitus is associated with both insulin secretion defect and insulin resistance. The primary metabolic defect leading to type 2 diabetes mellitus has been thought to be varied among populations, especially in Japanese and Caucasians. Here, we have done the genome-wide scan for type 2 diabetes mellitus using 102 affected Japanese sib-pairs to identify the genetic factors predisposing to type 2 diabetes mellitus. Nonparametric linkage analysis showed one suggestive evidence for linkage to 11p13-p12 [D11S905: two-point maximum LOD score (MLS) of 2.89 and multipoint MLS of 2.32] and one nominally significant evidence for linkage to 6q15-q16 (D6S462: two-point MLS of 2.02). Interestingly, the 11p13-p12 region was reported to be a susceptibility locus for Japanese type 2 diabetes mellitus with suggestive evidence of linkage, and D11S905 was within 5 cM to D11S935 with the highest MLS in the previous linkage analysis reported. The only overlapped susceptibility region with suggestive evidence of linkage for Japanese type 2 diabetes mellitus was D11S935 D11S905 among the three reports including this study. These results taken together suggest that a susceptibility gene for type 2 diabetes mellitus in Japanese will reside in 11p13-p12.

引用

页码：629 / 634

页数：6

共 44 条

[11] Further evidence for a susceptibility locus on chromosome 10p14-p11 in 72 families with schizophrenia by nonparametric linkage analysis
Schwab, SG
Hallmayer, J
Albus, M
Lerer, B
Hanses, C
Kanyas, K
Segman, R
Borrman, M
Dreikorn, B
Lichtermann, D
Rietschel, M
Trixler, M
Maier, W
Wildenauer, DB
AMERICAN JOURNAL OF MEDICAL GENETICS, 1998, 81 (04): : 302 - 307
[12] Genome-wide screen in obese pedigrees with type 2 diabetes mellitus from a defined Dutch population
van Tilburg, JH
Sandkuijl, LA
Franke, L
Strengman, E
Pearson, PL
van Haeften, TW
Wijmenga, C
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2003, 33 (12) : 1070 - 1074
[13] Genome-Wide Significance and Replication of the Chromosome 12p11.22 Locus Near the PTHLH Gene for Peripartum Cardiomyopathy
Horne, Benjamin D.
Rasmusson, Kismet D.
Alharethi, Rami
Budge, Deborah
Brunisholz, Kimberly D.
Metz, Torri
Carlquist, John F.
Connolly, Jennifer J.
Porter, T. Flint
Lappe, Donald L.
Muhlestein, Joseph B.
Silver, Robert
Stehlik, Josef
Park, James J.
May, Heidi T.
Bair, Tami L.
Anderson, Jeffrey L.
Renlund, Dale G.
Kfoury, Abdallah G.
CIRCULATION-CARDIOVASCULAR GENETICS, 2011, 4 (04) : 359 - U63
[14] SNP in the genome-wide association study hotspot on chromosome 9p21 confers susceptibility to diabetic nephropathy in type 1 diabetes
Fagerholm, E.
Ahlqvist, E.
Forsblom, C.
Sandholm, N.
Syreeni, A.
Parkkonen, M.
McKnight, A. J.
Tarnow, L.
Maxwell, A. P.
Parving, H. -H.
Groop, L.
Groop, P. -H.
DIABETOLOGIA, 2012, 55 (09) : 2386 - 2393
[15] Functional annotations of diabetes nephropathy susceptibility loci through analysis of genome-wide renal gene expression in rat models of diabetes mellitus
Hu, Yaomin
Kaisaki, Pamela J.
Argoud, Karene
Wilder, Steven P.
Wallace, Karin J.
Woon, Peng Y.
Blancher, Christine
Tarnow, Lise
Groop, Per-Henrik
Hadjadj, Samy
Marre, Michel
Parving, Hans-Henrik
Farrall, Martin
Cox, Roger D.
Lathrop, Mark
Vionnet, Nathalie
Bihoreau, Marie-Therese
Gauguier, Dominique
BMC MEDICAL GENOMICS, 2009, 2
[16] Genome-Wide Linkage Analysis of Obsessive-Compulsive Disorder Implicates Chromosome 1p36
Mathews, Carol A.
Badner, Judith A.
Andresen, J. Michael
Sheppard, Brooke
Himle, Joseph A.
Grant, Jon E.
Williams, Kyle A.
Chavira, Denise A.
Azzam, Amin
Schwartz, Maxine
Reus, Victor I.
Kim, Suck Won
Cook, Edwin H.
Hanna, Gregory L.
BIOLOGICAL PSYCHIATRY, 2012, 72 (08) : 629 - 636
[17] Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis
van Es, Michael A.
Veldink, Jan H.
Saris, Christiaan G. J.
Blauw, Hylke M.
van Vught, Paul W. J.
Birve, Anna
Lemmens, Robin
Schelhaas, Helenius J.
Groen, Ewout J. N.
Huisman, Mark H. B.
van der Kooi, Anneke J.
de Visser, Marianne
Dahlberg, Caroline
Estrada, Karol
Rivadeneira, Fernando
Hofman, Albert
Zwarts, Machiel J.
van Doormaal, Perry T. C.
Rujescu, Dan
Strengman, Eric
Giegling, Ina
Muglia, Pierandrea
Tomik, Barbara
Slowik, Agnieszka
Uitterlinden, Andre G.
Hendrich, Corinna
Waibel, Stefan
Meyer, Thomas
Ludolph, Albert C.
Glass, Jonathan D.
Purcell, Shaun
Cichon, Sven
Noethen, Markus M.
Wichmann, H-Erich
Schreiber, Stefan
Vermeulen, Sita H. H. M.
Kiemeney, Lambertus A.
Wokke, John H. J.
Cronin, Simon
McLaughlin, Russell L.
Hardiman, Orla
Fumoto, Katsumi
Pasterkamp, R. Jeroen
Meininger, Vincent
Melki, Judith
Leigh, P. Nigel
Shaw, Christopher E.
Landers, John E.
Al-Chalabi, Ammar
Brown, Robert H., Jr.
NATURE GENETICS, 2009, 41 (10) : 1083 - U53
[18] Genome-wide interaction with the insulin secretion locus MTNR1B reveals CMIP as a novel type 2 diabetes susceptibility gene in African Americans
Keaton, Jacob M.
Gao, Chuan
Guan, Meijian
Hellwege, Jacklyn N.
Palmer, Nicholette D.
Pankow, James S.
Fornage, Myriam
Wilson, James G.
Correa, Adolfo
Rasmussen-Torvik, Laura J.
Rotter, Jerome I.
Chen, Yii-Der I.
Taylor, Kent D.
Rich, Stephen S.
Wagenknecht, Lynne E.
Freedman, Barry I.
Ng, Maggie C. Y.
Bowden, Donald W.
GENETIC EPIDEMIOLOGY, 2018, 42 (06) : 559 - 570
[19] Replication of 13 genome-wide association (GWA)-validated risk variants for type 2 diabetes in Pakistani populations
Rees, S. D.
Hydrie, M. Z. I.
Shera, A. S.
Kumar, S.
O'Hare, J. P.
Barnett, A. H.
Basit, A.
Kelly, M. A.
DIABETOLOGIA, 2011, 54 (06) : 1368 - 1374
[20] A genome-wide linkage study of bipolar disorder and co-morbid migraine: Replication of migraine linkage on chromosome 4q24, and suggestion of an overlapping susceptibility region for both disorders on chromosome 20p11
Oedegaard, K. J.
Greenwood, T. A.
Lunde, A.
Fasmer, O. B.
Akiskal, H. S.
Kelsoe, J. R.
JOURNAL OF AFFECTIVE DISORDERS, 2010, 122 (1-2) : 14 - 26

← 1 2 3 4 5 →