Joining the interface: a site for Nmd3 association on 60S ribosome subunits

被引：2
|
作者：
Oeffinger, Marlene [1 ]
机构：
[1] Inst Rech Clin Montreal, Lab Biochim Ribonucleoprot, Montreal, PQ H2W 1R7, Canada
来源：
JOURNAL OF CELL BIOLOGY | 2010年 / 189卷 / 07期
关键词：
NUCLEAR EXPORT; SACCHAROMYCES-CEREVISIAE; PROTEIN; RPL10P; BIOGENESIS; REQUIRES; ADAPTER;
D O I：
10.1083/jcb.201006033
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The adaptor protein Nmd3 is required for Crm1-dependent export of large ribosomal subunits from the nucleus. In this issue, Sengupta et al. (2010. J. Cell Biol. doi:10.1083/jcb.201001124) identify a binding site for yeast Nmd3 on 60S ribosomal subunits using cryoelectron microscopy and suggest a conformational model for its release in the cytoplasm. The study provides the first detailed structural description of a ribosome biogenesis factor in complex with the large subunit.
引用
收藏
页码：1071 / 1073
页数：3
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