Stance of MRD in Non-Hodgkin's Lymphoma and its upsurge in the novel era of cell-free DNA

被引：2

作者：

Garg, S. ^{[1
]}

Kumar, A. ^{[2
]}

Gupta, R. ^{[1
]}

机构：

[1] All India Inst Med Sci AIIMS, Dr BRA IRCH, Lab Oncol Unit, New Delhi 110029, India

[2] AIIMS, Natl Canc Inst, Med Oncol Dept, Jhajjar, Haryana, India

来源：

CLINICAL & TRANSLATIONAL ONCOLOGY | 2021年 / 23卷 / 11期

关键词：

Minimal residual disease; Non-Hodgkin’ s Lymphoma; Cell-free DNA; Circulating tumor DNA; Advanced molecular techniques; LARGE B-CELL; MINIMAL RESIDUAL DISEASE; CIRCULATING TUMOR DNA; POLYMERASE-CHAIN-REACTION; LUNG-CANCER PATIENTS; DROPLET DIGITAL PCR; PLASMA DNA; FOLLICULAR LYMPHOMA; WALDENSTROM MACROGLOBULINEMIA; MICROSATELLITE ALTERATIONS;

D O I：

10.1007/s12094-021-02635-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer genomics has evolved over the years from understanding the pathogenesis of cancer to screening the future possibilities of cancer occurrence. Understanding the genetic profile of tumors holds a prognostic as well as a predictive value in this era of therapeutic surveillance, molecular remission, and precision medicine. Identifying molecular markers in tumors is the current standard of approach, and requires an efficient combination of an accessible sample type and a profoundly sensitive technique. Liquid biopsy or cell-free DNA has evolved as a novel sample type with promising results in recent years. Although cell-free DNA has significant role in various cancer types, this review focuses on its application in Non-Hodgkin's Lymphoma. Beginning with the current concept and clinical relevance of minimal residual disease in Non-Hodgkin's lymphoma, we discuss the literature on circulating DNA and its evolving application in the realm of cutting-edge technology.

引用

页码：2206 / 2219

页数：14

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