Solid-phase synthesis of lipidated peptides

被引：40
作者：
Kragol, G
Lumbierres, M
Palomo, JM
Waldmann, H
机构：
[1] Max Planck Inst Mol Physiol, Abt Chem Biol, D-44227 Dortmund, Germany
[2] Univ Dortmund, Fachbereich 3, D-44221 Dortmund, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 43期
关键词：
lipids; proteins; solid-phase synthesis;
D O I：
10.1002/anie.200461150
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Blockers, anchors, and reporters: A solid-phase method for the synthesis of lipidated peptides (see scheme) relies on the base-labile Fmoc group to block the N-terminus, an oxidation-labile hydrazide linker for anchoring to the solid support, and lipidated amino acid building blocks incorporating labels or photoactivatable groups.
引用
收藏
页码：5839 / 5842
页数：4
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