Melatonin-based therapeutics for atherosclerotic lesions and beyond: Focusing on macrophage mitophagy

被引：27

作者：

Ajoolabady, Amir ^{[1
,2
]}

Bi, Yaguang ^{[2
]}

McClements, David J. ^{[3
]}

Lip, Gregory Y. H. ^{[4
,5
,6
]}

Richardson, Des R. ^{[7
,8
,9
,10
]}

Reiter, Russel J. ^{[11
]}

Klionsky, Daniel J. ^{[12
,13
,14
]}

Ren, Jun ^{[1
,2
,15
]}

机构：

[1] Univ Wyoming, Coll Hlth Sci, Laramie, WY 82071 USA

[2] Fudan Univ, Shanghai Inst Cardiovasc Dis, Dept Cardiol, Zhongshan Hosp, Shanghai 200032, Peoples R China

[3] Univ Massachusetts, Dept Food Sci, Amherst, MA 01003 USA

[4] Univ Liverpool, Liverpool, Merseyside, England

[5] Liverpool Heart & Chest Hosp, Liverpool, Merseyside, England

[6] Aalborg Univ, Dept Clin Med, Aalborg, Denmark

[7] Univ Sydney, Dept Pathol, Mol Pharmacol & Pathol Program, Sydney, NSW 2006, Australia

[8] Univ Sydney, Bosch Inst, Sydney, NSW 2006, Australia

[9] Nagoya Univ, Dept Pathol & Biol Responses, Grad Sch Med, Nagoya, Aichi 4668550, Japan

[10] Griffith Univ, Ctr Canc Cell Biol & Drug Discovery, Griffith Inst Drug Discovery, Brisbane, Qld 4111, Australia

[11] Univ Texas Hlth Sci Ctr San Antonio, Dept Cellular & Struct Biol, San Antonio, TX 78229 USA

[12] Univ Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA

[13] Univ Michigan, Dept Mol Cellular & Dev Biol, Ann Arbor, MI 48109 USA

[14] Univ Michigan, Dept Biol Chem, Ann Arbor, MI 48109 USA

[15] Univ Washington, Dept Lab Med & Pathol, Seattle, WA 98195 USA

来源：

PHARMACOLOGICAL RESEARCH | 2022年 / 176卷

关键词：

Atherosclerosis; Macrophages; Melatonin; Mitophagy; Therapeutics; ACTIVATED PROTEIN-KINASE; SOLID LIPID NANOPARTICLES; RESPIRATORY COMPLEX-I; ENHANCES MITOPHAGY; MITOCHONDRIAL DYSFUNCTION; MYOCARDIAL-INFARCTION; MEDIATES MITOPHAGY; OXIDATIVE STRESS; DELIVERY-SYSTEMS; TARGETING FOXO3;

D O I：

10.1016/j.phrs.2022.106072

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Atherosclerosis refers to a unique form of chronic proinflammatory anomaly of the vasculature, presented as rupture-prone or occlusive lesions in arteries. In advanced stages, atherosclerosis leads to the onset and development of multiple cardiovascular diseases with lethal consequences. Inflammatory cytokines in atherosclerotic lesions contribute to the exacerbation of atherosclerosis. Pharmacotherapies targeting dyslipidemia, hypercholesterolemia, and neutralizing inflammatory cytokines (TNF-alpha, IL-1 beta, IL-6, IL-17, and IL-12/23) have displayed proven promises although contradictory results. Moreover, adjuvants such as melatonin, a pluripotent agent with proven anti-inflammatory, anti-oxidative and neuroprotective properties, also display potentials in alleviating cytokine secretion in macrophages through mitophagy activation. Here, we share our perspectives on this concept and present melatonin-based therapeutics as a means to modulate mitophagy in macrophages and, thereby, ameliorate atherosclerosis.

引用

页数：14

共 186 条

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