Bioengineering Hematopoietic Stem Cell Niche toward Regenerative Medicine

被引：17

作者：

Sugimura, Ryohichi

机构：

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2016年 / 99卷

关键词：

Hematopoietic stem cell; niche; organoid; bioengineering; organ on a chip; ON-A-CHIP; MESENCHYMAL STROMAL CELLS; UMBILICAL-CORD BLOOD; BONE-MARROW NICHE; SELF-RENEWAL; N-CADHERIN; ENDOTHELIAL-CELLS; BETA-CATENIN; PROGENITOR CELLS; ADULT;

D O I：

10.1016/j.addr.2015.10.010

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The scope of this chapter is to introduce the current consensus of hematopoietic stem cell (HSC) niche biology to bioengineering field so that can apply to regenerative medicine. A decade of research has been addressing "what is HSC niche", then next step is "how it advances medicine". The demand to improve HSC transplantation has advanced the methodology to expand HSC in vitro. Still precise modeling of bone marrow (BM) is demanded by bioengineering HSC niche in vitro. Better understanding of HSC niche is essential toward this progress. Now it would be the time to apply the knowledge of HSC niche field to the venue of bioengineering, so that a promising new approach to regenerative medicine might appear. This chapter describes the current consensus of niche that endothelial cell and perivascular mesenchymal stromal cell maintain HSC, expansion of cord blood HSC by small molecules, bioengineering efforts to model HSC niche by microfluidics chip, organoids, and breakthroughs to induce HSC from heterologous types of cells. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：212 / 220

页数：9

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