Nanotechnology: Its Application in Treating Neurodegenerative Diseases

被引：13
作者：
Naz, Falaq [1 ]
Siddique, Yasir Hasan [1 ]
机构：
[1] Aligarh Muslim Univ, Fac Life Sci, Dept Zool, Sect Genet,Drosophila Transgen Lab, Aligarh 202002, Uttar Pradesh, India
来源：
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS | 2021年 / 20卷 / 01期
关键词：
Nanotechnology; nanoparticles; neurodegenerative disease; Alzheimer's disease; Parkinson's disease; Huntington's disease; BLOOD-BRAIN-BARRIER; SOLID LIPID NANOPARTICLES; LOADED CHITOSAN NANOPARTICLES; CERIUM OXIDE NANOPARTICLES; AMYLOID-BETA AGGREGATION; DRUG-DELIVERY SYSTEMS; DUAL-FUNCTIONAL NANOPARTICLES; RECEPTOR-RELATED PROTEIN-1; PEG-PLGA NANOPARTICLES; ALZHEIMERS-DISEASE;
D O I：
10.2174/1871527319666200916121515
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Neurodegenerative diseases such as Alzheimer's, Parkinson's and Huntington disease have serious concern due to its effect on the quality of life of affected persons. They have some limitations at diagnostic as well as the treatment level. Introducing nanotechnology, for the treatment of these diseases may contribute significantly to solve the problem. There are several treatment strategies for the neurodegenerative diseases, but most of them fail to cross the Blood-Brain Barrier (BBB). The present review highlights the application of nanotechnology during last the 20 years for the treatment of neurodegenerative diseases.
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页码：34 / 53
页数：20
相关论文
共 229 条
[91]   Antiparkinsonian effect of nerve growth factor adsorbed on polybutylcyanoacrylate nanoparticles coated with polysorbate-80 [J].
Kurakhmaeva, K. B. ;
Voronina, T. A. ;
Kapica, I. G. ;
Kreuter, J. ;
Nerobkova, L. N. ;
Seredenin, S. B. ;
Balabanian, V. Yu. ;
Alyautdin, R. N. .
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2008, 145 (02) :259-262
[92]   Brain targeting of nerve growth factor using poly(butyl cyanoacrylate) nanoparticles [J].
Kurakhmaeva, Kamila B. ;
Djindjikhashvili, Irma A. ;
Petrov, Valery E. ;
Balabanyan, Vadim U. ;
Voronina, Tatiana A. ;
Trofimov, Sergey S. ;
Kreuter, Joerg ;
Gelperina, Svetlana ;
Begley, David ;
Alyautdin, Renad N. .
JOURNAL OF DRUG TARGETING, 2009, 17 (08) :564-574
[93]   Mitochondria-Targeting Ceria Nanoparticles as Antioxidants for Alzheimer's Disease [J].
Kwon, Hyek Jin ;
Cha, Moon-Yong ;
Kim, Dokyoon ;
Kim, Dong Kyu ;
Soh, Min ;
Shin, Kwangsoo ;
Hyeon, Taeghwan ;
Mook-Jung, Inhee .
ACS NANO, 2016, 10 (02) :2860-2870
[94]   Negatively Charged Gold Nanoparticles Inhibit Alzheimer's Amyloid-β Fibrillization, Induce Fibril Dissociation, and Mitigate Neurotoxicity [J].
Liao, Yi-Hung ;
Chang, Yu-Jen ;
Yoshiike, Yuji ;
Chang, Yun-Chorng ;
Chen, Yun-Ru .
SMALL, 2012, 8 (23) :3631-3639
[95]  
Lindner GD, 2015, NANOMEDICINE-UK, V10, P1127, DOI [10.2217/nnm.14.165, 10.2217/NNM.14.165]
[96]   A Highly Sensitive Gold-Nanoparticle-Based Assay for Acetylcholinesterase in Cerebrospinal Fluid of Transgenic Mice with Alzheimer's Disease [J].
Liu, Dingbin ;
Chen, Wenwen ;
Tian, Yue ;
He, Sha ;
Zheng, Wenfu ;
Sun, Jiashu ;
Wang, Zhuo ;
Jiang, Xingyu .
ADVANCED HEALTHCARE MATERIALS, 2012, 1 (01) :90-95
[97]  
Liu Gang, 2009, J Nanoneurosci, V1, P42
[98]   Nanoparticle-chelator conjugates as inhibitors of amyloid-β aggregation and neurotoxicity: A novel therapeutic approach for Alzheimer disease [J].
Liu, Gang ;
Men, Ping ;
Kudo, Wataru ;
Perry, George ;
Smith, Mark A. .
NEUROSCIENCE LETTERS, 2009, 455 (03) :187-190
[99]   Brain-targeted co-delivery of therapeutic gene and peptide by multifunctional nanoparticles in Alzheimer's disease mice [J].
Liu, Yang ;
An, Sai ;
Li, Jianfeng ;
Kuang, Yuyang ;
He, Xi ;
Guo, Yubo ;
Ma, Haojun ;
Zhang, Yu ;
Ji, Bin ;
Jiang, Chen .
BIOMATERIALS, 2016, 80 :33-45
[100]   Targeting Caspase-3 as Dual Therapeutic Benefits by RNAi Facilitating Brain-Targeted Nanoparticles in a Rat Model of Parkinson's Disease [J].
Liu, Yang ;
Guo, Yubo ;
An, Sai ;
Kuang, Yuyang ;
He, Xi ;
Ma, Haojun ;
Li, Jianfeng ;
Lv, Jing ;
Zhang, Ning ;
Jiang, Chen .
PLOS ONE, 2013, 8 (05)
567891011121314