Nanotechnology: Its Application in Treating Neurodegenerative Diseases

被引:13
作者
Naz, Falaq [1 ]
Siddique, Yasir Hasan [1 ]
机构
[1] Aligarh Muslim Univ, Fac Life Sci, Dept Zool, Sect Genet,Drosophila Transgen Lab, Aligarh 202002, Uttar Pradesh, India
关键词
Nanotechnology; nanoparticles; neurodegenerative disease; Alzheimer's disease; Parkinson's disease; Huntington's disease; BLOOD-BRAIN-BARRIER; SOLID LIPID NANOPARTICLES; LOADED CHITOSAN NANOPARTICLES; CERIUM OXIDE NANOPARTICLES; AMYLOID-BETA AGGREGATION; DRUG-DELIVERY SYSTEMS; DUAL-FUNCTIONAL NANOPARTICLES; RECEPTOR-RELATED PROTEIN-1; PEG-PLGA NANOPARTICLES; ALZHEIMERS-DISEASE;
D O I
10.2174/1871527319666200916121515
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Neurodegenerative diseases such as Alzheimer's, Parkinson's and Huntington disease have serious concern due to its effect on the quality of life of affected persons. They have some limitations at diagnostic as well as the treatment level. Introducing nanotechnology, for the treatment of these diseases may contribute significantly to solve the problem. There are several treatment strategies for the neurodegenerative diseases, but most of them fail to cross the Blood-Brain Barrier (BBB). The present review highlights the application of nanotechnology during last the 20 years for the treatment of neurodegenerative diseases.
引用
收藏
页码:34 / 53
页数:20
相关论文
共 229 条
[1]   Nanotechnology platforms in Parkinson's Disease [J].
Adhikary, Rishi Rajat ;
Sandbhor, Puja ;
Banerjee, Rinti .
ADMET AND DMPK, 2015, 3 (03) :155-181
[2]   Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs [J].
Agrawal, Mukta ;
Saraf, Swarnlata ;
Saraf, Shailendra ;
Antimisiaris, Sophia G. ;
Chougule, Mahavir Bhupal ;
Shoyele, Sunday A. ;
Alexander, Amit .
JOURNAL OF CONTROLLED RELEASE, 2018, 281 :139-177
[3]   Nose-to-brain drug delivery approach: a key to easily accessing the brain for the treatment of Alzheimer's disease [J].
Alexander, Amit ;
Saraf, Shailendra .
NEURAL REGENERATION RESEARCH, 2018, 13 (12) :2102-2104
[4]   Anthocyanin-Loaded PEG-Gold Nanoparticles Enhanced the Neuroprotection of Anthocyanins in an Aβ1-42 Mouse Model of Alzheimer's Disease [J].
Ali, Tahir ;
Kim, Min Ju ;
Rehman, Shafiq Ur ;
Ahmad, Ashfaq ;
Kim, Myeong Ok .
MOLECULAR NEUROBIOLOGY, 2017, 54 (08) :6490-6506
[5]  
[Anonymous], 2008, NANOTECHNOLOGY DRUG
[6]  
[Anonymous], P INT C PROD ENG T 2
[7]  
Arulkumar S., 2010, Int. J. Res. Pharm. Sci, V1, P417
[8]   Organically Modified Silica Nanoparticles Are Biocompatible and Can Be Targeted to Neurons In Vivo [J].
Barandeh, Farda ;
Phuong-Lan Nguyen ;
Kumar, Rajiv ;
Iacobucci, Gary J. ;
Kuznicki, Michelle L. ;
Kosterman, Andrew ;
Bergey, Earl J. ;
Prasad, Paras N. ;
Gunawardena, Shermali .
PLOS ONE, 2012, 7 (01)
[9]   A macrophage-nanozyme delivery system for Parkinson's disease [J].
Batrakova, Elena V. ;
Li, Shu ;
Reynolds, Ashley D. ;
Mosley, R. Lee ;
Bronich, Tatiana K. ;
Kabanov, Alexander V. ;
Gendelman, Howard E. .
BIOCONJUGATE CHEMISTRY, 2007, 18 (05) :1498-1506
[10]   Nose to brain delivery of rotigotine loaded chitosan nanoparticles in human SH-SY5Y neuroblastoma cells and animal model of Parkinson's disease [J].
Bhattamisra, Subrat K. ;
Shak, Angeline Tzeyung ;
Xi, Lim Wen ;
Safian, Nurul Hasyanazifa ;
Choudhury, Hira ;
Lim, Wei Meng ;
Shahzad, Naiyer ;
Alhakamy, Nabil A. ;
Anwer, Md Khalid ;
Radhakrishnan, Ammu K. ;
Md, Shadab .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2020, 579