Cytokine profiles in polymyositis and dermatomyositis complicated by rapidly progressive or chronic interstitial lung disease

被引:182
作者
Gono, Takahisa [1 ]
Kaneko, Hirotaka [1 ]
Kawaguchi, Yasushi [1 ]
Hanaoka, Masanori [1 ]
Kataoka, Sayuri [1 ]
Kuwana, Masataka [2 ]
Takagi, Kae [1 ]
Ichida, Hisae [1 ]
Katsumata, Yasuhiro [1 ]
Ota, Yuko [1 ]
Kawasumi, Hidenaga [1 ]
Yamanaka, Hisashi [1 ]
机构
[1] Tokyo Womens Med Univ, Inst Rheumatol, Tokyo 1620054, Japan
[2] Keio Univ, Sch Med, Dept Internal Med, Tokyo, Japan
关键词
polymyositis; dermatomyositis; interstitial lung disease; TNF-alpha; IL-6; IL-8; CLINICALLY AMYOPATHIC DERMATOMYOSITIS; GENE; 5; ADULT; BIOMARKERS; DYSREGULATION; AUTOANTIGEN; EXPRESSION; CHEMOKINES; SEVERITY; JUVENILE;
D O I
10.1093/rheumatology/keu258
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. PM and DM are often complicated by interstitial lung disease (ILD). In this study we aimed to evaluate various serum cytokines in patients with PM/DM with ILD so as to clarify the differences in pathophysiology between anti-melanoma differentiation-associated gene 5 antibody-associated ILD (anti-MDA5-ILD) and anti-aminoacyl tRNA synthetase antibody-associated ILD (anti-ARS-ILD). Methods. We evaluated the serum cytokine profiles of 38 patients with PM/DM and compared the cytokine profiles of the non-ILD and ILD subsets as well as the anti-MDA5-ILD and anti-ARS-ILD subsets. Results. The myositis intention-to-treat activity index score, which indicates whole disease activity, significantly correlated with serum IL-6, IL-8, TNF-alpha and IP-10. These cytokine levels were significantly higher in the ILD subset than the non-ILD subset and were lower in the ILD subset following treatment. By multivariate analysis, TNF-alpha was the most significant cytokine [P = 0.0006, odds ratio (OR) 1.4, CI 1.1, 2.2] associated with PM/DM with ILD. IL-8 levels were significantly higher in anti-MDA5-ILD than in anti-ARS-ILD, although IL-6, TNF-alpha and IP-10 levels were high in both subsets. IL-8 was the most significant cytokine (P = 0.0006, OR 1.5, CI 1.1, 3.0) associated with anti-MDA5-ILD by multivariate analysis. Moreover, the ratio of IL-4 to IFN-gamma was lower in anti-MDA5-ILD than in anti-ARS-ILD. Conclusion. IL-6, IL-8, TNF-alpha and IP-10 are associated with global disease activity in PM/DM. These cytokine levels were high, especially in the ILD subset. Serum IL-8 levels and the balance between IL-4 and IFN-gamma may contribute to the differences in pathophysiology between anti-ARS-ILD and anti-MDA5-ILD.
引用
收藏
页码:2196 / 2203
页数:8
相关论文
共 33 条
[1]   Pathogenetic and predictive value of biomarkers in patients with ALI and lower severity of illness: results from two clinical trials [J].
Agrawal, Ashish ;
Zhuo, Hanjing ;
Brady, Sandra ;
Levitt, Joseph ;
Steingrub, Jay ;
Siegel, Mark D. ;
Soto, Graciela ;
Peterson, Michael W. ;
Chesnutt, Mark S. ;
Matthay, Michael A. ;
Liu, Kathleen D. .
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2012, 303 (08) :L634-L639
[2]  
American Thoracic Society, 2002, Am J Respir Crit Care Med, V165, P277
[3]   Macrophage-Derived Biomarkers of Idiopathic Pulmonary Fibrosis [J].
Bargagli, E. ;
Prasse, A. ;
Olivieri, C. ;
Muller-Quernheim, J. ;
Rottoli, P. .
PULMONARY MEDICINE, 2011, 2011
[4]  
BENFIELD TL, 1995, AM J RESP CRIT CARE, V151, P1058
[5]   Interleukin-6 and Type I Interferon-Regulated Genes and Chemokines Mark Disease Activity in Dermatomyositis [J].
Bilgic, Hatice ;
Ytterberg, Steven R. ;
Amin, Shreyasee ;
McNallan, Kelly T. ;
Wilson, Joseph C. ;
Koeuth, Thearith ;
Ellingson, Sonja ;
Newman, Brant ;
Bauer, Jason W. ;
Peterson, Erik J. ;
Baechler, Emily C. ;
Reed, Ann M. .
ARTHRITIS AND RHEUMATISM, 2009, 60 (11) :3436-3446
[6]   POLYMYOSITIS AND DERMATOMYOSITIS .1. [J].
BOHAN, A ;
PETER, JB .
NEW ENGLAND JOURNAL OF MEDICINE, 1975, 292 (07) :344-347
[7]   Acute interstitial pneumonia: report of a series [J].
Bonaccorsi, A ;
Cancellieri, A ;
Chilosi, M ;
Trisolini, R ;
Boaron, M ;
Crimi, N ;
Poletti, V .
EUROPEAN RESPIRATORY JOURNAL, 2003, 21 (01) :187-191
[8]   Dermatomyositis [J].
Callen, JP .
LANCET, 2000, 355 (9197) :53-57
[9]   Role of cytokines and chemokines in idiopathic inflammatory myopathies [J].
De Paepe, Boel ;
Creus, Kim K. ;
De Bleecker, Jan L. .
CURRENT OPINION IN RHEUMATOLOGY, 2009, 21 (06) :610-616
[10]   Idiopathic Inflammatory Myopathies: Current Trends in Pathogenesis, Clinical Features, and Up-to-Date Treatment Recommendations [J].
Ernste, Floranne C. ;
Reed, Ann M. .
MAYO CLINIC PROCEEDINGS, 2013, 88 (01) :83-105