Development of indole-based fluorescent probe for detection of fluoride and cell imaging of HepG2

被引：38

作者：

Wang, Qin ^{[1
]}

Li, Dan ^{[1
]}

Rao, Nian ^{[1
]}

Zhang, Yan ^{[1
]}

Le, Yi ^{[1
,2
]}

Liu, Li ^{[1
,2
]}

Huang, Lei ^{[3
,4
,5
]}

Yan, Longjia ^{[1
,2
,3
]}

机构：

[1] Guizhou Univ, Sch Pharmaceut Sci, Guiyang 550025, Peoples R China

[2] Guizhou Univ, Guizhou Engn Lab Synthet Drugs, Guiyang 550025, Peoples R China

[3] Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550014, Peoples R China

[4] Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550014, Peoples R China

[5] Chinese Acad Sci, Guiyang 550014, Peoples R China

来源：

DYES AND PIGMENTS | 2021年 / 188卷

关键词：

Fluorescence; Probe; Fluoride ion; HepG2; cell; Endemic disease; SENSOR; ION;

D O I：

10.1016/j.dyepig.2021.109166

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A fluorescent probe IDS based on indole ring was designed and synthesized. It has been successfully developed for highly selective detection of fluoride ions with a low detection of 1.3 ppb. Besides, the probe IDS was used for fluorescence imaging of F- in HepG2 cells and detected the concentration of fluoride ions in the environmental water samples and urine sample. These applications suggested that IDS was a sensitive probe in research and potential for the diagnosis of endemic fluorosis.

引用

页数：7

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