Mandibular Brown Tumor as a Result of Secondary Hyperparathyroidism: A Case Report with 5 Years Follow-Up and Review of the Literature

被引:15
作者
Shavlokhova, Veronika [1 ]
Goeppert, Benjamin [2 ]
Gaida, Matthias M. [2 ,3 ]
Saravi, Babak [4 ]
Weichel, Frederic [1 ]
Vollmer, Andreas [1 ]
Vollmer, Michael [1 ]
Freudlsperger, Christian [1 ]
Mertens, Christian [1 ]
Hoffmann, Juergen [1 ]
机构
[1] Univ Hosp Heidelberg, Dept Oral & Craniomaxillofacial Surg, D-69120 Heidelberg, Germany
[2] Univ Hosp Heidelberg, Inst Pathol, D-69120 Heidelberg, Germany
[3] Johannes Gutenberg Univ Mainz, Univ Med Ctr Mainz, Inst Pathol, D-55131 Mainz, Germany
[4] Albert Ludwigs Univ Freiburg, Fac Med, Med Ctr, Dept Orthoped & Trauma Surg, D-79106 Freiburg, Germany
关键词
brown tumor; secondary hyperparathyroidism; jaw; radical resection; microvascular reconstruction; FLAPS;
D O I
10.3390/ijerph18147370
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Background: Brown tumor is a rare skeletal manifestation of secondary hyperparathyroidism. Although diagnosis of the disease is increasingly seen in early stages due to improved screening techniques, some patients still present in a progressed disease stage. The treatment depends on tumor mass and varies from a conservative approach with supportive parathyroidectomy to extensive surgical resection with subsequent reconstruction. Case presentation: We report a case of extensive mandibular brown tumor in a patient with a history of systemic lupus erythematosus, chronic kidney disease, and secondary hyperparathyroidism. Following radical resection of the affected bone, reconstruction could be successfully performed using a free flap. Conclusions: There were no signs of recurrence during five years of close follow-up. Increased awareness and multidisciplinary follow-ups could allow early diagnosis and prevent the need for radical therapeutical approaches.
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页数:11
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