Osteoporosis in men

被引：8

作者：

Moro-Alvarez, M. J. ^{[2
]}

Blazquez Cabrera, J. A. ^{[1
]}

机构：

[1] Complejo Hosp Univ Albacete, Med Interna Serv, Albacete, Spain

[2] Hosp Cent de la Cruz Roja, Med Interna Serv, Unidad Metab Mineral & Oseo, Madrid, Spain

来源：

REVISTA CLINICA ESPANOLA | 2010年 / 210卷 / 07期

关键词：

Osteoporosis; Osteopenia; Man; Male hypogonadism; Fractures; Prevention; Treatment; Bisphosphonates; Teriparatide; Testosterone; ANDROGEN-DEPRIVATION THERAPY; BONE-MINERAL DENSITY; PROSTATE-CANCER; OLDER MEN; ZOLEDRONIC ACID; HIP FRACTURE; RISK-FACTORS; SECONDARY OSTEOPOROSIS; ALENDRONATE TREATMENT; VERTEBRAL FRACTURES;

D O I：

10.1016/j.rce.2009.11.023

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Osteoporosis in men continues to be underdiagnosed and undertreated. Its presence makes it necessary to rule out predisposing conditions and diseases. General prevention measures should be recommended and when necessary also supplementation with 1200 mg/day of calcium and at least 800 IU/day of vitamin D. Bisphosphonates, specifically alendronate (ALN) and risedronate (RSN), are the treatment of choice in men with osteoporosis. In severe cases with high risk of fracture and in patients with therapeutic failure with the bisphosphonates or who do not tolerate these drugs, the use of teriparatide may be recommended. The evidence available suggests that anti-fracture efficacy of treatment with ALN, RSN and teriparatide is similar in both genders. Androgens are only justified if there is clinical hypogonadism. Even in this case, bisphosphonates or teriparatide should probably be associated if the risk of fracture is very high in spite of androgen replacement. (C) 2009 Elsevier Espana, S.L. All rights reserved.

引用

页码：342 / 349

页数：8

共 61 条

[1] Exogenous testosterone or testosterone with finasteride increases bone mineral density in older men with low serum testosterone [J].

Amory, JK ;

Watts, NB ;

Easley, KA ;

Sutton, PR ;

Anawalt, BD ;

Matsumoto, AM ;

Bremner, WJ ;

Tenover, JL .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (02) :503-510

[2] Androgen supplementation in eugonadal men with osteoporosis - Effects of 6 months of treatment on bone mineral density and cardiovascular risk factors [J].

Anderson, FH ;

Francis, RM ;

Faulkner, K .

BONE, 1996, 18 (02) :171-177

[3] Low levels of estradiol are associated with vertebral fractures in older men, but not women:: The Rancho Bernardo study [J].

Barrett-Connor, E ;

Mueller, JE ;

Von Mühlen, DG ;

Laughlin, GA ;

Schneider, DL ;

Sartoris, DJ .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2000, 85 (01) :219-223

[4] Intravenous Zoledronic Acid to Prevent Osteoporosis in a Veteran Population With Multiple Risk Factors for Bone Loss on Androgen Deprivation Therapy [J].

Bhoopalam, Nirmala ;

Campbell, Steven C. ;

Moritz, Thomas ;

Broderick, William R. ;

Iyer, Padmini ;

Arcenas, Anthony G. ;

Van Veldhuizen, Peter J. ;

Friedman, Nicholas ;

Reda, Domenic ;

Warren, Stuart ;

Garewal, Harinder .

JOURNAL OF UROLOGY, 2009, 182 (05) :2257-2264

[5] Management of cancer treatment-induced bone loss in early breast and prostate cancer - a consensus paper of the Belgian Bone Club [J].

Body, J. J. ;

Bergmann, P. ;

Boonen, S. ;

Boutsen, Y. ;

Devogelaer, J. P. ;

Goemaere, S. ;

Reginster, J. Y. ;

Rozenberg, S. ;

Kaufman, J. M. .

OSTEOPOROSIS INTERNATIONAL, 2007, 18 (11) :1439-1450

[6] Mortality after all major types of osteoporotic fracture in men and women: an observational study [J].

Center, JR ;

Nguyen, TV ;

Schneider, D ;

Sambrook, PN ;

Eisman, JA .

LANCET, 1999, 353 (9156) :878-882

[7] BMD and risk of hip and nonvertebral fractures in older men: A prospective study and comparison with older women [J].

Cummings, Steven R. ;

Cawthon, Peggy M. ;

Ensrud, Kristine E. ;

Cauley, Jane A. ;

Fink, Howard A. ;

Orwoll, Eric S. .

JOURNAL OF BONE AND MINERAL RESEARCH, 2006, 21 (10) :1550-1556

[8] Osteoporosis and spinal fractures in men with prostate cancer: Risk factors and effects of androgen deprivation therapy [J].

Diamond, TH ;

Bucci, J ;

Kersley, JH ;

Aslan, P ;

Lynch, WB ;

Bryant, C .

JOURNAL OF UROLOGY, 2004, 172 (02) :529-532

[9] Osteoporosis in men [J].

Ebeling, Peter R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (14) :1474-1482

[10] INCREASES IN BONE-DENSITY DURING TREATMENT OF MEN WITH IDIOPATHIC HYPOGONADOTROPIC HYPOGONADISM [J].

FINKELSTEIN, JS ;

KLIBANSKI, A ;

NEER, RM ;

DOPPELT, SH ;

ROSENTHAL, DI ;

SEGRE, GV ;

CROWLEY, WF .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1989, 69 (04) :776-783

← 1 2 3 4 5 6 7 →