Small pancreatic ductal carcinomas on triple-phase contrast-enhanced computed tomography: enhanced rims and the pathologic correlation

被引:1
作者
Takaji, Ryo [1 ]
Yamada, Yasunari [1 ]
Matsumoto, Shunro [1 ]
Kiyonaga, Maki [1 ]
Hongo, Norio [1 ]
Mori, Hiromu [1 ]
Hijiya, Naoki [2 ]
Ohta, Masayuki [3 ]
Inomata, Masafumi [3 ]
Takaki, Hajime [4 ]
Fukuzawa, Kengo [5 ]
Yonemasu, Hirotoshi [6 ]
机构
[1] Oita Univ, Dept Radiol, Fac Med, Oita 8795593, Japan
[2] Oita Univ, Dept Mol Pathol, Fac Med, Oita 8795593, Japan
[3] Oita Univ, Dept Gastroenterol & Pediat Surg, Fac Med, Oita 8795593, Japan
[4] Oita Red Cross Hosp, Dept Radiol, Oita 8700033, Japan
[5] Oita Red Cross Hosp, Dept Surg, Oita 8700033, Japan
[6] Oita Red Cross Hosp, Dept Anat Pathol, Oita 8700033, Japan
基金
日本学术振兴会;
关键词
Small pancreatic ductal carcinoma; Triple-phase contrast-enhanced CT; Enhanced rim; Pathologic correlation; SOLID PSEUDOPAPILLARY NEOPLASMS; ACINAR-CELL CARCINOMA; SECONDARY SIGNS; DIFFERENTIATION; CANCER; CT; FIBROBLASTS; ADENOCARCINOMAS; SURVIVAL; FEATURES;
D O I
10.1007/s00261-018-1645-6
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
PurposeTo reveal the prevalence of small (20mm) pancreatic ductal carcinomas with enhanced rims on triple-phase contrast-enhanced CT and correlate the CT images with the pathologic findings.Materials and methodsBetween April 2005 and April 2016, 45 patients underwent preoperative triple-phase contrast-enhanced CT and were pathologically diagnosed with small pancreatic ductal carcinoma. CT images were independently reviewed by two radiologists. The attenuation values of the enhanced rims, internal areas of the tumors, and surrounding pancreatic parenchyma were compared using Mann-Whitney U test. These areas were also correlated with the pathologic findings. Tumor invasiveness was compared between the tumors with and without enhanced rims using Fisher's exact test.ResultsEnhanced rims were identified in 18 tumors (40%) by consensus between the two reviewers. The enhanced rims showed significantly higher mean attenuation values compared with the internal areas of the tumors (p<0.001) and surrounding pancreatic parenchyma (p<0.0086),and were most clearly visualized on equilibrium phase. The enhanced rims pathologically reflected the abundant fibrotic stroma with cancer cells in all tumors. There was no statistically significant difference in tumor invasiveness between the tumors with and without enhanced rims (anterior peripancreatic invasion, p=0.137; posterior peripancreatic invasion, p=0.758; portal vein invasion, p=0.639; and lymph node metastases, p=0.359).ConclusionsEnhanced rims were detected at a rate of 40% in small pancreatic ductal carcinomas and could be an important finding for diagnosis on CT images, but did not suggest a less aggressive nature.
引用
收藏
页码:3374 / 3380
页数:7
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