TCR engineered T cells for solid tumor immunotherapy

被引：38

作者：

Zhang, Yikai ^{[1
,2
,3
,4
]}

Liu, Zhipeng ^{[1
,2
]}

Wei, Wei ^{[1
,2
]}

Li, Yangqiu ^{[3
,4
]}

机构：

[1] Guangzhou Municipal Tianhe Nuoya Bioengn Co Ltd, Guangzhou 510663, Peoples R China

[2] Guangdong Cord Blood Bank, Guangzhou 510663, Peoples R China

[3] Jinan Univ, Affiliated Hosp 1, Dept Hematol, Guangzhou 510632, Peoples R China

[4] Jinan Univ, Sch Med, Inst Hematol, Key Lab Regenerat Med,Minist Educ, 601 Huang Pu Dao Xi, Guangzhou 510632, Peoples R China

来源：

EXPERIMENTAL HEMATOLOGY & ONCOLOGY | 2022年 / 11卷 / 01期

基金：

中国博士后科学基金;

关键词：

T cell receptor; TCR-T cells; Cellular immunotherapy; Solid tumors; RECEPTOR GENE-THERAPY; CANCER REGRESSION; ADOPTIVE TRANSFER; LYMPHOCYTES; MELANOMA; TRIAL; MICROENVIRONMENT; IDENTIFICATION; SPECIFICITY; RECOGNITION;

D O I：

10.1186/s40164-022-00291-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

T cell immunotherapy remains an attractive approach for cancer immunotherapy. T cell immunotherapy mainly employs chimeric antigen receptor (CAR)- and T cell receptor (TCR)-engineered T cells. CAR-T cell therapy has been an essential breakthrough in treating hematological malignancies. TCR-T cells can recognize antigens expressed both on cell surfaces and in intracellular compartments. Although TCR-T cells have not been approved for clinical application, a number of clinical trials have been performed, particularly for solid tumors. In this article, we summarized current TCR-T cell advances and their potential advantages for solid tumor immunotherapy.

引用

页数：11

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