TCR engineered T cells for solid tumor immunotherapy

被引：38
作者：
Zhang, Yikai [1 ,2 ,3 ,4 ]
Liu, Zhipeng [1 ,2 ]
Wei, Wei [1 ,2 ]
Li, Yangqiu [3 ,4 ]
机构：
[1] Guangzhou Municipal Tianhe Nuoya Bioengn Co Ltd, Guangzhou 510663, Peoples R China
[2] Guangdong Cord Blood Bank, Guangzhou 510663, Peoples R China
[3] Jinan Univ, Affiliated Hosp 1, Dept Hematol, Guangzhou 510632, Peoples R China
[4] Jinan Univ, Sch Med, Inst Hematol, Key Lab Regenerat Med,Minist Educ, 601 Huang Pu Dao Xi, Guangzhou 510632, Peoples R China
来源：
EXPERIMENTAL HEMATOLOGY & ONCOLOGY | 2022年 / 11卷 / 01期
基金：
中国博士后科学基金;
关键词：
T cell receptor; TCR-T cells; Cellular immunotherapy; Solid tumors; RECEPTOR GENE-THERAPY; CANCER REGRESSION; ADOPTIVE TRANSFER; LYMPHOCYTES; MELANOMA; TRIAL; MICROENVIRONMENT; IDENTIFICATION; SPECIFICITY; RECOGNITION;
D O I：
10.1186/s40164-022-00291-0
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
T cell immunotherapy remains an attractive approach for cancer immunotherapy. T cell immunotherapy mainly employs chimeric antigen receptor (CAR)- and T cell receptor (TCR)-engineered T cells. CAR-T cell therapy has been an essential breakthrough in treating hematological malignancies. TCR-T cells can recognize antigens expressed both on cell surfaces and in intracellular compartments. Although TCR-T cells have not been approved for clinical application, a number of clinical trials have been performed, particularly for solid tumors. In this article, we summarized current TCR-T cell advances and their potential advantages for solid tumor immunotherapy.
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页数：11
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共 106 条
  • [1] T-cell receptor gene therapy of established tumors in a murine melanoma model
    Abad, John D.
    Wrzensinski, Claudia
    Overwijk, Willem
    De Witte, Moniek A.
    Jorritsma, Annelies
    Hsu, Cary
    Gattinoni, Luca
    Cohen, Cyrille J.
    Paulos, Chrystal M.
    Palmer, Douglas C.
    Haanen, John B. A. G.
    Schumacher, Ton N. M.
    Rosenberg, Steven A.
    Restifo, Nicholas P.
    Morgan, Richard A.
    [J]. JOURNAL OF IMMUNOTHERAPY, 2008, 31 (01) : 1 - 6
  • [2] Expression profiling of TCR-engineered T cells demonstrates overexpression of multiple inhibitory receptors in persisting lymphocytes
    Abate-Daga, Daniel
    Hanada, Ken-ichi
    Davis, Jeremy L.
    Yang, James C.
    Rosenberg, Steven A.
    Morgan, Richard A.
    [J]. BLOOD, 2013, 122 (08) : 1399 - 1410
  • [3] Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy
    Bendle, Gavin M.
    Linnemann, Carsten
    Hooijkaas, Anna I.
    Bies, Laura
    de Witte, Moniek A.
    Jorritsma, Annelies
    Kaiser, Andrew D. M.
    Pouw, Nadine
    Debets, Reno
    Kieback, Elisa
    Uckert, Wolfgang
    Song, Ji-Ying
    Haanen, John B. A. G.
    Schumacher, Ton N. M.
    [J]. NATURE MEDICINE, 2010, 16 (05) : 565 - U98
  • [4] TALEN-mediated editing of endogenous T-cell receptors facilitates efficient reprogramming of T lymphocytes by lentiviral gene transfer
    Berdien, B.
    Mock, U.
    Atanackovic, D.
    Fehse, B.
    [J]. GENE THERAPY, 2014, 21 (06) : 539 - 548
  • [5] T-Cell Receptor-Based Immunotherapy for Hematologic Malignancies
    Biernacki, Melinda A.
    Brault, Michelle
    Bleakley, Marie
    [J]. CANCER JOURNAL, 2019, 25 (03) : 179 - 190
  • [6] The CC and CXC chemokines: major regulators of tumor progression and the tumor microenvironment
    Bikfalvi, Andreas
    Billottet, Clotilde
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2020, 318 (03): : C542 - C554
  • [7] Toxicity and management in CAR T-cell therapy
    Bonifant, Challice L.
    Jackson, Hollie J.
    Brentjens, Renier J.
    Curran, Kevin J.
    [J]. MOLECULAR THERAPY-ONCOLYTICS, 2016, 3 : 16011
  • [8] Vγ9Vδ2 T cell-mediated recognition of human solid tumors.: Potential for immunotherapy of hepatocellular and colorectal carcinomas
    Bouet-Toussaint, Francoise
    Cabillic, Florian
    Toutirais, Olivier
    Le Gallo, Matthieu
    de la Pintiere, Cecile Thomas
    Daniel, Pascale
    Genetet, Noelle
    Meunier, Bernard
    Dupont-Bierre, Eric
    Boudjema, Karim
    Catros, Veronique
    [J]. CANCER IMMUNOLOGY IMMUNOTHERAPY, 2008, 57 (04) : 531 - 539
  • [9] RNAi-mediated TCR Knockdown Prevents Autoimmunity in Mice Caused by Mixed TCR Dimers Following TCR Gene Transfer
    Bunse, Mario
    Bendle, Gavin M.
    Linnemann, Carsten
    Bies, Laura
    Schulz, Stephan
    Schumacher, Ton N.
    Uckert, Wolfgang
    [J]. MOLECULAR THERAPY, 2014, 22 (11) : 1983 - 1991
  • [10] T cell receptor-based cancer immunotherapy: Emerging efficacy and pathways of resistance
    Chandran, Smita S.
    Klebanoff, Christopher A.
    [J]. IMMUNOLOGICAL REVIEWS, 2019, 290 (01) : 127 - 147
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