Total synthesis of rodgersinol: a survey of the Cu(II)-mediated coupling of ortho-substituted phenols

被引：6

作者：

Jung, Jong-Wha ^{[1
]}

Jang, Jaebong ^{[1
]}

Seo, Seung-Yong ^{[2
]}

Jung, Jae-Kyung ^{[3
]}

Suh, Young-Ger ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

[2] Woosuk Univ, Coll Pharm, Wonju 565701, South Korea

[3] Chungbuk Natl Univ, Coll Pharm, Cheongju 361763, South Korea

来源：

TETRAHEDRON | 2010年 / 66卷 / 34期

关键词：

ALPHA-ARYLPROPANOIC ACIDS; DIARYL ETHER SYNTHESIS; ASYMMETRIC DIHYDROXYLATION; CONCISE SYNTHESIS; COPPER; DERIVATIVES; CATALYSTS; EPOXIDES; AGENTS; ROUTE;

D O I：

10.1016/j.tet.2010.06.048

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Full details of studies directed toward the total synthesis of both enantiomers of rodgersinol are described. The key parts of our synthetic route to rodgersinol included the Cu(II)-mediated coupling of an arylboronic acid with an ortho-alkyl substituted phenol and regio- and stereoselective construction of the hydroxypropyl substituent. which avoided tedious protection/deprotection sequence. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：6826 / 6831

页数：6

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