Total synthesis of rodgersinol: a survey of the Cu(II)-mediated coupling of ortho-substituted phenols

被引：6
|
作者：
Jung, Jong-Wha [1 ]
Jang, Jaebong [1 ]
Seo, Seung-Yong [2 ]
Jung, Jae-Kyung [3 ]
Suh, Young-Ger [1 ]
机构：
[1] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea
[2] Woosuk Univ, Coll Pharm, Wonju 565701, South Korea
[3] Chungbuk Natl Univ, Coll Pharm, Cheongju 361763, South Korea
来源：
TETRAHEDRON | 2010年 / 66卷 / 34期
关键词：
ALPHA-ARYLPROPANOIC ACIDS; DIARYL ETHER SYNTHESIS; ASYMMETRIC DIHYDROXYLATION; CONCISE SYNTHESIS; COPPER; DERIVATIVES; CATALYSTS; EPOXIDES; AGENTS; ROUTE;
D O I：
10.1016/j.tet.2010.06.048
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Full details of studies directed toward the total synthesis of both enantiomers of rodgersinol are described. The key parts of our synthetic route to rodgersinol included the Cu(II)-mediated coupling of an arylboronic acid with an ortho-alkyl substituted phenol and regio- and stereoselective construction of the hydroxypropyl substituent. which avoided tedious protection/deprotection sequence. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6826 / 6831
页数：6
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