Association between exposure to polycyclic aromatic hydrocarbons and lipid peroxidation in patients with chronic obstructive pulmonary disease

被引：17

作者：

Liu, Jinming ^{[1
]}

Chen, Xi ^{[1
]}

Qiu, Xinghua ^{[1
]}

Zhang, Hanxiyue ^{[1
]}

Lu, Xinchen ^{[1
]}

Li, Haonan ^{[1
]}

Chen, Wu ^{[1
]}

Zhang, Lina ^{[2
]}

Que, Chengli ^{[3
]}

Zhu, Tong ^{[1
]}

机构：

[1] Peking Univ, Coll Environm Sci & Engn, Ctr Environm & Hlth, State Key Joint Lab Environm Simulat & Pollut Con, Beijing 100871, Peoples R China

[2] Shichahai Community Hlth Ctr, Beijing 100035, Peoples R China

[3] Peking Univ, Hosp 1, Beijing 100034, Peoples R China

来源：

SCIENCE OF THE TOTAL ENVIRONMENT | 2021年 / 780卷

基金：

中国国家自然科学基金;

关键词：

Chronic obstructive pulmonary disease (COPD); Lung function; Malonaldehyde (MDA); Oxidative stress; Polycyclic aromatic hydrocarbons (PAHs); OXIDATIVE STRESS; AIR-POLLUTION; CIRCULATING BIOMARKERS; RISK ASSESSMENT; PAHS; METABOLITES; HEALTHY; DAMAGE;

D O I：

10.1016/j.scitotenv.2021.146660

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Polycyclic aromatic hydrocarbons (PAHs) are toxic airborne pollutants and may cause adverse effects at high level of oxidative stress. Here we hypothesized that individuals with impaired lung function are susceptible to PAHs associated oxidative damage. Hence, we carried out a panel study and conducted four follow-up visits on 40 chronic obstructive pulmonary disease (COPD) patients and 75 healthy controls. Hydroxylated PAHs (OHPAHs) and malonaldehyde (MDA) were measured in urine as exposure and oxidative stress markers, respectively, which showed significant association in all participants. Quantitatively, a 1-fold increase in OH-PAHs was associated with a 4.1-15.1% elevation of MDA. The association between OH-PAHs and MDA levels became stronger in participants with impaired lung function. For 1% decrease of FEV1/FVC, the increase of MDA associated with a 1-fold increase in OH-PAHs was up to 0.49%, suggesting an increased susceptibility to PAH-induced oxidative damage in individuals with worse lung function. This study observed that impaired lung function modified the association between PAH exposure and oxidative damage, which might accelerate the aggravation of COPD, and therefore highlighted the necessity of protection measures to decrease the additional adverse effects of air pollution exposure. Capsule: Individuals with worse lung function may be more susceptible to PAH-induced lipid peroxidation. (c) 2021 Elsevier B.V. All rights reserved.

引用

页数：6