Richer gut microbiota with distinct metabolic profile in HIV infected Elite Controllers

被引：73

作者：

Vesterbacka, Jan ^{[1
]}

Rivera, Javier ^{[2
]}

Noyan, Kajsa ^{[3
]}

Parera, Mariona ^{[2
]}

Neogi, Ujjwal ^{[3
]}

Calle, Malu ^{[4
]}

Paredes, Roger ^{[2
,4
,5
,6
,7
]}

Sonnerborg, Anders ^{[1
,3
]}

Noguera-Julian, Marc ^{[2
,4
]}

Nowak, Piotr ^{[1
]}

机构：

[1] Karolinska Univ Hosp, Dept Med Huddinge, Unit Infect Dis, Karolinska Inst, Stockholm, Sweden

[2] Univ Autonoma Barcelona, IrsiCaixa & AIDS Unit, Hosp Univ Germans Trias & Pujol, Badalona, Spain

[3] Karolinska Univ Hosp, Dept Lab Med, Div Clin Microbiol, Karolinska Inst, Stockholm, Sweden

[4] Univ Vic Univ Cent Catalunya, Catalonia, Spain

[5] Univ Autonoma Barcelona, Bellaterra 08193, Catalonia, Spain

[6] Hosp Badalona Germans Trias & Pujol, HIV Unit, Ctra Canyet S-N, Badalona 08916, Catalonia, Spain

[7] Hosp Badalona Germans Trias & Pujol, Lluita SIDA Fdn, Ctra Canyet S-N, Badalona 08916, Catalonia, Spain

来源：

SCIENTIFIC REPORTS | 2017年 / 7卷

基金：

瑞典研究理事会;

关键词：

T-CELL-ACTIVATION; SYSTEMIC IMMUNE ACTIVATION; DOUBLE-BLIND; TRYPTOPHAN; TRANSLOCATION; MUCOSAL; INFLAMMATION; PATHOGENESIS; TOLERANCE; BACTERIA;

D O I：

10.1038/s41598-017-06675-1

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Gut microbiota dysbiosis features progressive HIV infection and is a potential target for intervention. Herein, we explored the microbiome of 16 elite controllers (EC), 32 antiretroviral therapy naive progressors and 16 HIV negative controls. We found that the number of observed genera and richness indices in fecal microbiota were significantly higher in EC versus naive. Genera Succinivibrio, Sutterella, Rhizobium, Delftia, Anaerofilum and Oscillospira were more abundant in EC, whereas Blautia and Anaerostipes were depleted. Additionally, carbohydrate metabolism and secondary bile acid synthesis pathway related genes were less represented in EC. Conversely, fatty acid metabolism, PPAR-signalling and lipid biosynthesis proteins pathways were enriched in EC vs naive. The kynurenine pathway of tryptophan metabolism was altered during progressive HIV infection, and inversely associated with microbiota richness. In conclusion, EC have richer gut microbiota than untreated HIV patients, with unique bacterial signatures and a distinct metabolic profile which may contribute to control of HIV.

引用

页数：13

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