New functions for coenzyme Q

被引：18
作者：
Crane, FL [1 ]
机构：
[1] Purdue Univ, Dept Biol Sci, W Lafayette, IN 47907 USA
来源：
PROTOPLASMA | 2000年 / 213卷 / 3-4期
关键词：
mitochondrion; oxygen radical; antioxidant; apoptosis; cell growth; iron transport;
D O I：
10.1007/BF01282150
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Coenzyme Q is primarily identified with its role in energy coupling where it is involved in the generation of a proton gradient across membranes to drive ATP formation. Its identification as a significant antioxidant throughout cellular membranes is developing. Its function in other membrane redox systems introduces new functions such as the generation of hydrogen peroxide related to cellular signal systems or the acidification of other organelles. A role in the control of cell growth and apoptosis has also been introduced.
引用
收藏
页码：127 / 133
页数：7
相关论文
共 81 条
[1]   DISTRIBUTION AND REDOX STATE OF UBIQUINONES IN RAT AND HUMAN TISSUES [J].
ABERG, F ;
APPELKVIST, EL ;
DALLNER, G ;
ERNSTER, L .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1992, 295 (02) :230-234
[2]   Increases in tissue levels of ubiquinone in association with peroxisome proliferation [J].
Aberg, F ;
Zhang, YY ;
Teclebrhan, H ;
Appelkvist, EL ;
Dallner, G .
CHEMICO-BIOLOGICAL INTERACTIONS, 1996, 99 (1-3) :205-218
[3]   IRON REVERSES IMPERMEABLE CHELATOR INHIBITION OF DNA-SYNTHESIS IN CCL-39 CELLS [J].
ALCAIN, FJ ;
LOW, H ;
CRANE, FL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (17) :7903-7906
[4]   IRON AT THE CELL-SURFACE CONTROLS BOTH DNA-SYNTHESIS AND PLASMA-MEMBRANE REDOX SYSTEM [J].
ALCAIN, FJ ;
LOW, H ;
CRANE, FL .
PROTOPLASMA, 1995, 184 (1-4) :233-237
[5]   Plasma membrane ubiquinone controls ceramide production and prevents cell death induced by serum withdrawal [J].
Barroso, MP ;
GomezDiaz, C ;
Villalba, JM ;
Buron, MI ;
LopezLluch, G ;
Navas, P .
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, 1997, 29 (03) :259-267
[6]  
BEYER RE, 1997, MOL ASPECTS MED, V18, P15
[7]  
BEYER RE, 1991, BIOMEDICAL CLIN ASPE, P501
[8]  
BIENFAIT HF, 1988, PLANT PHYSIOL BIOCH, V26, P665
[9]   Not all Shc's roads lead to Ras [J].
Bonfini, L ;
Migliaccio, E ;
Pelicci, G ;
Lanfrancone, L ;
Pelicci, P .
TRENDS IN BIOCHEMICAL SCIENCES, 1996, 21 (07) :257-261
[10]   Proton-translocation by membrane-bound NADH:ubiquinone-oxidoreductase (complex I) through redox-gated ligand conduction [J].
Brandt, U .
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 1997, 1318 (1-2) :79-91
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