The Role of Family-Based Designs in Genome-Wide Association Studies

被引：19
作者：
Laird, Nan M. [1 ]
Lange, Christoph [1 ]
机构：
[1] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA
来源：
STATISTICAL SCIENCE | 2009年 / 24卷 / 04期
关键词：
Genetic association; TDT; FBAT; PBAT; two-stage designs; GENETIC-ASSOCIATION; GENOTYPING ERRORS; TRANSMISSION/DISEQUILIBRIUM TEST; LINKAGE DISEQUILIBRIUM; GENERAL-CLASS; TESTS; POWER; TRANSMISSION; INFORMATION; TRAITS;
D O I：
10.1214/08-STS280
中图分类号：
O21 [概率论与数理统计]; C8 [统计学];
学科分类号：
020208 ; 070103 ; 0714 ;
摘要：
Genome-Wide Association Studies (GWAS) offer an exciting and promising new research avenue for finding genes for complex diseases. Traditional case-control and cohort studies offer many advantages for such designs. Family-based association designs have long been attractive for their robustness properties, but robustness can mean a loss of power. In this paper we discuss some of the special features of family designs and their relevance in the era of GWAS.
引用
收藏
页码：388 / 397
页数：10
相关论文
共 50 条
[41]   Genome-Wide Association Studies of Family Data in Pharmacogenetics: A Case Study [J].
Murphy, Amy ;
Lasky-Su, Jessica ;
Tantisira, Kelan G. ;
Litonjua, Augusto A. ;
Lange, Christoph ;
Weiss, Scott T. .
CURRENT PHARMACEUTICAL DESIGN, 2009, 15 (32) :3764-3772
[42]   Genome-Wide Association Studies and Beyond [J].
Witte, John S. .
ANNUAL REVIEW OF PUBLIC HEALTH, VOL 31, 2010, 31 :9-20
[43]   Systematic review of genome-wide association studies of abdominal aortic aneurysm [J].
Singh, Tejas P. ;
Field, Matt A. ;
Bown, Matthew J. ;
Jones, Gregory T. ;
Golledge, Jonathan .
ATHEROSCLEROSIS, 2021, 327 :39-48
[44]   Meta-analysis methods for genome-wide association studies and beyond [J].
Evangelou, Evangelos ;
Ioannidis, John P. A. .
NATURE REVIEWS GENETICS, 2013, 14 (06) :379-389
[45]   Transfer Learning in Genome-Wide Association Studies with Knockoffs [J].
Li, Shuangning ;
Ren, Zhimei ;
Sabatti, Chiara ;
Sesia, Matteo .
SANKHYA-SERIES B-APPLIED AND INTERDISCIPLINARY STATISTICS, 2022,
[46]   A new association test based on disease allele selection for case-control genome-wide association studies [J].
Chen, Zhongxue .
BMC GENOMICS, 2014, 15
[47]   Genome-wide association studies for waxy starch in cassava [J].
do Carmo, Catia Dias ;
Sousa, Massaine Bandeira E. ;
Brito, Ana Carla ;
de Oliveira, Eder Jorge .
EUPHYTICA, 2020, 216 (05)
[48]   The meta-analysis of genome-wide association studies [J].
Thompson, John R. ;
Attia, John ;
Minelli, Cosetta .
BRIEFINGS IN BIOINFORMATICS, 2011, 12 (03) :259-269
[49]   The HapMap and Genome-Wide Association Studies in Diagnosis and Therapy [J].
Manolio, Teri A. ;
Collins, Francis S. .
ANNUAL REVIEW OF MEDICINE, 2009, 60 :443-456
[50]   Meta-analysis in genome-wide association studies [J].
Zeggini, E. ;
Ioannidis, J. P. A. .
PHARMACOGENOMICS, 2009, 10 (02) :191-201
12345