International high-risk clone of fluoroquinolone-resistant Escherichia coli O15:H1-D-ST393 in remote communities of Brazilian Amazon

被引：3
作者：
Vianello, Marco Aurelio [1 ]
Cardoso, Brenda [2 ]
Fuentes-Castillo, Danny [3 ]
Moura, Quezia [4 ]
Esposito, Fernanda [5 ]
Fuga, Bruna [2 ,5 ]
Lincopan, Nilton [2 ,5 ]
Egito, Eryvaldo Socrates T. [1 ]
机构：
[1] Univ Fed Rio Grande do Norte, Grad Program Hlth Sci, Natal, RN, Brazil
[2] Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, Sao Paulo, Brazil
[3] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Pathol, Sao Paulo, Brazil
[4] Fed Univ Grande Dourados, Fac Hlth Sci, Dourados, MS, Brazil
[5] Univ Sao Paulo, Dept Clin Anal, Fac Pharm, Sao Paulo, Brazil
来源：
INFECTION GENETICS AND EVOLUTION | 2021年 / 91卷
基金：
巴西圣保罗研究基金会;
关键词：
ExPEC; Ciprofloxacin-resistant; Multidrug-resistant; Enterobacterales; Fecal carriage; Clonal complex CC31; ANTIBIOTIC-RESISTANCE; EXTENDED-SPECTRUM; EXTRAINTESTINAL INFECTIONS; MULTIDRUG-RESISTANT; GENES; VIRULENCE; LINEAGES; SPREAD; ST405; ST131;
D O I：
10.1016/j.meegid.2021.104808
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The global dissemination of multidrug-resistant Escherichia coli lineages belonging to high- risk clones poses a significant public health threat. Herein we report the identification and genomic profiling of two multidrugresistant E. coli strains [BL-II-03(2) and BL-II-11(3)] belonging to the O15:H1-D-ST393 (clonal complex 31) worldwide spread clone, isolated from fecal samples of indigenous peoples belonging to two different ethnic groups of remote communities of Brazilian Amazon. Genomic analysis revealed genes and mutations conferring resistance to beta-lactams [blaTEM-1], aminoglycosides [aadA5, aph(3 '')-Ib, aph(6)-Id], tetracyclines [tetB], sulfamethoxazole/trimethoprim [sul1, sul2, dfrA17], and fluoroquinolones [gyrA (D87N, S83L), parC (S80I, S57T), parE (L416F)]; and presence of IncQ1, IncFIA, and IncFIB(pB171) plasmids. On the other hand, phylogenomics of globally reported E. coli ST393 assigned E. coli strains BL-II-03(2) and BL-II-11(3) to a cluster comprising human isolates from Australia, Canada, China, Sweden, and United States of America. These results might provide valuable information for understanding dissemination of intercontinental multidrug-resistant clones in remote communities with low levels of antibiotic exposure.
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