Electric field causes volumetric changes in the human brain

被引：61

作者：

Argyelan, Miklos ^{[1
,2
,3
]}

Oltedal, Leif ^{[4
,5
]}

Deng, Zhi-De ^{[6
]}

Wade, Benjamin ^{[7
]}

Bikson, Marom ^{[8
]}

Joanlanne, Andrea ^{[1
]}

Sanghani, Sohag ^{[1
]}

Bartsch, Hauke ^{[5
,9
]}

Cano, Marta ^{[10
,11
]}

Dale, Anders M. ^{[9
,12
,13
]}

Dannlowski, Udo ^{[14
]}

Dols, Annemiek ^{[15
]}

Enneking, Verena ^{[14
]}

Espinoza, Randall ^{[16
,17
]}

Kessler, Ute ^{[4
,18
]}

Narr, Katherine L. ^{[16
,17
]}

Oedegaard, Ketil J. ^{[4
,18
]}

Oudega, Mardien L. ^{[15
]}

Redlich, Ronny ^{[14
]}

Stek, Max L. ^{[15
]}

Takamiya, Akihiro ^{[19
,20
]}

Emsell, Louise ^{[21
]}

Bouckaert, Filip ^{[21
,22
]}

Sienaert, Pascal ^{[22
]}

Pujol, Jesus ^{[11
,23
]}

Tendolkar, Indira ^{[24
,25
,26
,27
]}

van Eijndhoven, Philip ^{[24
,25
]}

Petrides, Georgios ^{[1
,2
,3
]}

Malhotra, Anil K. ^{[1
,2
,3
]}

Abbott, Christopher ^{[28
]}

机构：

[1] Zucker Hillside Hosp, Dept Psychiat, Glen Oaks, NY 11004 USA

[2] Feinstein Inst Med Res, Ctr Neurosci, Manhasset, NY 11030 USA

[3] Zucker Sch Med, Dept Psychiat, Hempstead, NY 11549 USA

[4] Univ Bergen, Dept Clin Med, Bergen, Norway

[5] Haukeland Hosp, Mohn Med Imaging & Visualizat Ctr, Dept Radiol, Bergen, Norway

[6] NIMH, Expt Therapeut & Pathophysiol Branch, Bethesda, MD 20892 USA

[7] Univ Calif Los Angeles, Dept Neurol, Ahmanson Lovelace Brain Mapping Ctr, Los Angeles, CA 90024 USA

[8] CUNY, City Coll, Dept Biomed Engn, New York, NY 10021 USA

[9] Univ Calif San Diego, Ctr Multimodal Imaging & Genet, San Diego, CA 92103 USA

[10] Bellvitge Univ Hosp IDIBELL, Dept Psychiat, Barcelona, Spain

[11] Carlos III Hlth Inst, CIBERSAM, Barcelona, Spain

[12] Univ Calif San Diego, Dept Radiol, San Diego, CA 92103 USA

[13] Univ Calif San Diego, Dept Neurosci, San Diego, CA 92103 USA

[14] Univ Munster, Dept Psychiat & Psychotherapy, Munster, Germany

[15] Amsterdam UMC, Old Age Psychiat, GGZinGeest, Locat VUmc,Dept Psychiat, Amsterdam, Netherlands

[16] Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA 90024 USA

[17] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA

[18] Univ Bergen, Haukeland Univ Hosp, Div Psychiat, Bergen, Norway

[19] Keio Univ, Dept Neuropsychiat, Sch Med, Tokyo, Japan

[20] Komagino Hosp, Ctr Psychiat & Behav Sci, Tokyo, Japan

[21] Katholieke Univ Leuven, Dept Geriatr Psychiat, Univ Psychiat Ctr, Leuven, Belgium

[22] Katholieke Univ Leuven, Acad Ctr ECT & Neurostimulat AcCENT, Univ Psychiat Ctr, Kortenberg, Belgium

[23] Hosp del Mar, Dept Radiol, Res Unit, MRI, Barcelona, Spain

[24] Radboud Univ Nijmegen, Dept Psychiat, Med Ctr, Nijmegen, Netherlands

[25] Donders Inst Brain Cognit & Behav, Ctr Cognit Neuroimaging, Nijmegen, Netherlands

[26] Univ Duisburg Essen, Fac Med, Essen, Germany

[27] Univ Duisburg Essen, LVR Clin Psychiat & Psychotherapy, Essen, Germany

[28] Univ New Mexico, Sch Med, Dept Psychiat, Albuquerque, NM 87131 USA

来源：

ELIFE | 2019年 / 8卷

关键词：

UNILATERAL ELECTROCONVULSIVE-THERAPY; DENTATE GYRUS; MATTER VOLUME; RATING-SCALE; DEPRESSION; NEUROGENESIS; HIPPOCAMPAL; ECT; SEIZURES; INCREASE;

D O I：

10.7554/eLife.49115

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Recent longitudinal neuroimaging studies in patients with electroconvulsive therapy (ECT) suggest local effects of electric stimulation (lateralized) occur in tandem with global seizure activity (generalized). We used electric field (EF) modeling in 151 ECT treated patients with depression to determine the regional relationships between EF, unbiased longitudinal volume change, and antidepressant response across 85 brain regions. The majority of regional volumes increased significantly, and volumetric changes correlated with regional electric field (t = 3.77, df = 83, r = 0.38, p=0.0003). After controlling for nuisance variables (age, treatment number, and study site), we identified two regions (left amygdala and left hippocampus) with a strong relationship between EF and volume change (FDR corrected p<0.01). However, neither structural volume changes nor electric field was associated with antidepressant response. In summary, we showed that high electrical fields are strongly associated with robust volume changes in a dose-dependent fashion.

引用

页数：20

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