Hemiaminal generated by hydration of ketone-based nitrone as an N,O-centered nucleophile in organic synthesis

被引：29

作者：

Ishikawa, T ^{[1
]}

Nagai, K ^{[1
]}

Senzaki, M ^{[1
]}

Tatsukawa, A ^{[1
]}

Saito, S ^{[1
]}

机构：

[1] Okayama Univ, Fac Engn, Dept Biosci & Biotechnol, Okayama 700, Japan

来源：

TETRAHEDRON | 1998年 / 54卷 / 11期

关键词：

D O I：

10.1016/S0040-4020(98)00008-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Isoxazolidines that are useful precursors for beta-amino acids have been prepared relying on intermolecular amino Michael addition-intramolecular S(N)2 displacement employing hydroxylamine or hydrate of ketone-based nitrone as an N- and O-centered binucleophile. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2433 / 2448

页数：16

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