Role of excitatory amino acid input in rostral ventrolateral medulla neurons in rats with obesity-induced hypertension

被引:0
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作者
Suhaimi, Farah Wahida [1 ]
Yusoff, Nurul Hasnida Mohammad [1 ]
Dewa, Aidiahmad [1 ]
Yusof, Ahmad Pauzi M. D. [2 ]
机构
[1] Univ Sains Malaysia, Sch Pharmaceut Sci, George Town 11800, Malaysia
[2] Masterskill Univ, Coll Hlth Sci, Cheras 43200, Selangor Darul, Malaysia
关键词
blood pressure; excitatory amino acid; hypertension; obesity; rostral ventrolateral medulla; SUPPORT BLOOD-PRESSURE; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; CHEMICAL-STIMULATION; GLUTAMATE RECEPTORS; ARTERIAL-PRESSURE; DIET; MODEL; ACTIVATION; REFLEXES; KIDNEY;
D O I
暂无
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Obesity is intimately associated with hypertension; increases in blood pressure are closely related to the magnitude of weight gain. The present study aims to determine whether the excitatory amino acid input to rostral ventrolateral medulla (RVLM) contributes to elevated blood pressure in rats with diet-induced obesity. Male Sprague-Dawley rats weighing 280 to 300 grams were fed with a low-fat diet (10% kcal from fat) or moderately high-fat diet (32% kcal from fat) for 16 weeks. At week 16, rats on the moderate high-fat diet were segregated into obesity-prone and obesity-resistant rats based on body weight distribution. Baseline mean arterial pressure (MAP) was significantly higher in obesity-prone rats as compared to obesity-resistant and rats on a low-fat diet. Bilateral injection of kynurenic acid (KYN) (40 nM) into the RVLM of the obesity-prone rats reduced MAP to levels significantly different from those observed in rats on a low-fat diet and obesity-resistant rats (no change in MAP). At a lower concentration (4 nM), KYN injection did not produce any change in MAP in any group. The results obtained suggest that excitatory amino acid input to the RVLM does contribute to the development of hypertension in rats with diet-induced obesity.
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页码:57 / 64
页数:8
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