Neolemnane-type sesquiterpenoids from a Formosan soft coral Paralemnalia thyrsoides

被引：32
作者：
Huang, Ho-Cheng
Chao, Chih-Hua
Su, Jui-Hsin
Hsu, Chi-Hsin
Chen, Shin-Pin
Kuo, Yao-Haur
Sheu, Jyh-Horng [1 ]
机构：
[1] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan
[2] Cheng Shiu Univ, Dept Chem & Mat Engn, Kaohsiung 833, Taiwan
[3] Natl Res Inst Chinese Med, Taipei 112, Taiwan
[4] Natl Sun Yat Sen Univ, Asian Pacific Ocean Res Ctr, Kaohsiung 804, Taiwan
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2007年 / 55卷 / 06期
关键词：
Paralemnalia thyrsoides; soft coral; sesquiterpenoid; paralemnolin;
D O I：
10.1248/cpb.55.876
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Six new sesquiterpenoids, paralemnolins D-I (1-6), have been isolated from the EtOAc extract of the soft coral Paralemnalia thyrsoides. The structures of these metabolites were determined by extensive spectroscopic analysis and by comparison of their spectral data with those of related metabolites. The absolute stereochemistry of these metabolites was established by application of the Mosher's method on I and on the basis of the absolute structures of other related compounds previously isolated from the soft corals of the genera Paralemnalia and Lemnalia. Cytotoxicity of these metabolites toward a limited panel of cancer cell lines also is reported.
引用
收藏
页码：876 / 880
页数：5
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