Prognostic significance of stomatin-like protein 2 overexpression in laryngeal squamous cell carcinoma: clinical, histologic, and immunohistochemistry analyses with tissue microarray

被引：39
作者：
Cao, Wen-feng
Zhang, Li-yong
Liu, Ming-bo
Tang, Ping-zhang
Liu, Zhi-hua
Sun, Bao-cun [1 ]
机构：
[1] Tianjin Med Univ, Canc Inst & Hosp, Dept Pathol, Tianjin 300060, Peoples R China
[2] Chinese Acad Med Sci, Canc Inst & Hosp, Natl Lab Mol Oncol, Beijing 100021, Peoples R China
[3] Peking Union Med Coll, Beijing 100021, Peoples R China
[4] Chinese Peoples Liberat Army, Gen Hosp, Dept Otolaryngol Head & Neck Surg, Beijing 100853, Peoples R China
[5] Chinese Acad Med Sci, Canc Inst & Hosp, Dept Otolaryngol Head & Neck Surg, Beijing 100021, Peoples R China
来源：
HUMAN PATHOLOGY | 2007年 / 38卷 / 05期
关键词：
laryngeal squamous cell carcinoma; SLP-2; tissue microarray;
D O I：
10.1016/j.humpath.2006.11.004
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Stomatin-like protein 2 (SLP-2) is a novel cancer-related gene whose product promotes cell growth, tumorigenicity, and adhesion ill human esophageal squamous cell carcinoma. The purpose of this Study was to investigate whether SLP-2 is overexpressed in human laryngeal squamous cell carcinoma (LSCC) and, if so, the significance of its overexpression in relation to clinical parameters. By analyzing 124 cases of LSCC with a tissue microarray, we concluded that SLP-2 is overexpressed in LSCC as compared with the adjacent normal laryngeal epithelium (P.000) and furthermore that SLP-2 expression correlates with clinical stage. Overexpression can be regarded as a significant prognostic factor, with higher expression being found in lymph node metastasis. (c) 2007 Published by Elsevier Inc.
引用
收藏
页码：747 / 752
页数：6
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