Endoplasmic reticulum stress and atherosclerosis

被引：245
作者：
Hotamisligil, Goekhan S. [1 ,2 ,3 ,4 ]
机构：
[1] Harvard Univ, Sch Publ Hlth, Dept Genet, Boston, MA 02115 USA
[2] Harvard Univ, Sch Publ Hlth, Dept Complex Dis, Boston, MA 02115 USA
[3] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA
[4] Harvard Univ, Sch Publ Hlth, Broad Inst, Massachusetts Inst Technol & Harvard, Boston, MA 02115 USA
来源：
NATURE MEDICINE | 2010年 / 16卷 / 04期
关键词：
UNFOLDED PROTEIN RESPONSE; INSULIN-RESISTANCE; ER STRESS; DEFICIENT MICE; APOLIPOPROTEIN-E; ADIPOSE-TISSUE; T-CELLS; OBESITY; APOPTOSIS; INFLAMMATION;
D O I：
10.1038/nm0410-396
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Atherosclerosis and related cardiovascular diseases represent one of the greatest threats to human health worldwide. Despite important progress in prevention and treatment, these conditions still account for one third of all deaths annually. Often presented together with obesity, insulin resistance and type 2 diabetes, these chronic diseases are strongly influenced by pathways that lie at the interface of chronic inflammation and nutrient metabolism. Here I discuss recent advances in the study of endoplasmic reticulum stress as one mechanism that links immune response with nutrient sensing in the pathogenesis of atherosclerosis and its complications.
引用
收藏
页码：396 / 399
页数：4
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