Poor survival after resection of early gastric cancer: extremes of survivorship analysis reveal distinct genomic profile

被引：14

作者：

Datta, J. ^{[1
,5
]}

Da Silva, E. M. ^{[2
]}

Kandoth, C. ^{[4
]}

Song, T. ^{[4
]}

Russo, A. E. ^{[1
]}

Hernandez, J. M. ^{[1
,6
]}

Taylor, B. S. ^{[4
]}

Janjigian, Y. Y. ^{[3
]}

Tang, L. H. ^{[2
]}

Solit, D. B. ^{[3
,4
]}

Strong, V. E. ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Surg, New York, NY 10065 USA

[2] Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10065 USA

[3] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA

[4] Mem Sloan Kettering Canc Ctr, Marie Josee & Henry R Kravis Ctr Mol Oncol, New York, NY 10065 USA

[5] Univ Miami, Miller Sch Med, Dept Surg, Sylvester Comprehens Canc Ctr, Miami, FL 33136 USA

[6] NIH, Thorac & Oncol Surg Branch, Bldg 10, Bethesda, MD 20892 USA

来源：

BRITISH JOURNAL OF SURGERY | 2020年 / 107卷 / 01期

关键词：

RECURRENCE; MUTATION;

D O I：

10.1002/bjs.11443

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

A subset of patients with early gastric cancer demonstrate early recurrence and poor survival despite margin-negative resection. This study used an extremes-of-survivorship approach to identify an association between TP53 hotspot mutations co-occurring with loss of heterozygosity and unexpectedly poor survival in early gastric cancer. This distinct genomic profile may be a novel biomarker of poor survival in patients with completely resected early gastric cancer, and warrants large-scale validation. Promising, validation needed

引用

页码：14 / 19

页数：6

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