E14a2 BCR-ABL1 transcript is associated with a higher rate of treatment-free remission in individuals with chronic myeloid leukemia after stopping tyrosine kinase inhibitor therapy

被引:43
作者
Claudiani, Simone [1 ]
Apperley, Jane F. [1 ]
Gale, Robert Peter [1 ]
Clark, Richard [2 ]
Szydlo, Richard [1 ]
Deplano, Simona [1 ]
Palanicawandar, Renuka [1 ]
Khorashad, Jamshid [1 ]
Foroni, Letizia [1 ]
Milojkovic, Dragana [1 ]
机构
[1] Imperial Coll Healthcare NHS Trust, Hammersmith Hosp, Dept Haematol, London, England
[2] Royal Liverpool Univ Hosp, Liverpool, Merseyside, England
关键词
CHRONIC MYELOGENOUS LEUKEMIA; MOLECULAR RESPONSE; YOUNG-ADULTS; IMATINIB; E13A2; TRIAL;
D O I
10.3324/haematol.2017.168740
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:E297 / E299
页数:3
相关论文
共 15 条
[1]   Differences among young adults, adults and elderly chronic myeloid leukemia patients [J].
Castagnetti, F. ;
Gugliotta, G. ;
Baccarani, M. ;
Breccia, M. ;
Specchia, G. ;
Levato, L. ;
Abruzzese, E. ;
Rossi, G. ;
Iurlo, A. ;
Martino, B. ;
Pregno, P. ;
Stagno, F. ;
Cuneo, A. ;
Bonifacio, M. ;
Gobbi, M. ;
Russo, D. ;
Gozzini, A. ;
Tiribelli, M. ;
de Vivo, A. ;
Alimena, G. ;
Cavo, M. ;
Martinelli, G. ;
Pane, F. ;
Saglio, G. ;
Rosti, G. .
ANNALS OF ONCOLOGY, 2015, 26 (01) :185-192
[2]   Direct evidence that leukemic cells present HLA-associated immunogenic peptides derived from the BCR-ABL b3a2 fusion protein [J].
Clark, RE ;
Dodi, IA ;
Hill, SC ;
Lill, JR ;
Aubert, G ;
Macintyre, AR ;
Rojas, J ;
Bourdon, A ;
Bonner, PLR ;
Wang, LH ;
Christmas, SE ;
Travers, PJ ;
Creaser, CS ;
Rees, RC ;
Madrigal, JA .
BLOOD, 2001, 98 (10) :2887-2893
[3]   Laboratory recommendations for scoring deep molecular responses following treatment for chronic myeloid leukemia [J].
Cross, N. C. P. ;
White, H. E. ;
Colomer, D. ;
Ehrencrona, H. ;
Foroni, L. ;
Gottardi, E. ;
Lange, T. ;
Lion, T. ;
Polakova, K. Machova ;
Dulucq, S. ;
Martinelli, G. ;
Leibundgut, E. Oppliger ;
Pallisgaard, N. ;
Barbany, G. ;
Sacha, T. ;
Talmaci, R. ;
Izzo, B. ;
Saglio, G. ;
Pane, F. ;
Mueller, M. C. ;
Hochhaus, A. .
LEUKEMIA, 2015, 29 (05) :999-1003
[4]   Deep molecular responses for treatment-free remission in chronic myeloid leukemia [J].
Dulucq, Stephanie ;
Mahon, Francois-Xavier .
CANCER MEDICINE, 2016, 5 (09) :2398-2411
[5]   Is there immune surveillance against chronic myeloid leukaemia? Possibly, but not much [J].
Gale, Robert Peter ;
Opelz, Gerhard .
LEUKEMIA RESEARCH, 2017, 57 :109-111
[6]   Distinct characteristics of e13a2 versus e14a2 BCR-ABL1 driven chronic myeloid leukemia under first-line therapy with imatinib [J].
Hanfstein, Benjamin ;
Lauseker, Michael ;
Hehlmann, Ruediger ;
Saussele, Susanne ;
Erben, Philipp ;
Dietz, Christian ;
Fabarius, Alice ;
Proetel, Ulrike ;
Schnittger, Susanne ;
Haferlach, Claudia ;
Krause, Stefan W. ;
Schubert, Joerg ;
Einsele, Hermann ;
Haenel, Mathias ;
Dengler, Jolanta ;
Falge, Christiane ;
Kanz, Lothar ;
Neubauer, Andreas ;
Kneba, Michael ;
Stegelmann, Frank ;
Pfreundschuh, Michael ;
Waller, Cornelius F. ;
Spiekermann, Karsten ;
Baerlocher, Gabriela M. ;
Pfirrmann, Markus ;
Hasford, Joerg ;
Hofmann, Wolf-Karsten ;
Hochhaus, Andreas ;
Mueller, Martin C. .
HAEMATOLOGICA, 2014, 99 (09) :1441-1447
[7]   Impact of BCR-ABL transcript type on outcome in patients with chronic-phase CML treated with tyrosine kinase inhibitors [J].
Jain, Preetesh ;
Kantarjian, Hagop ;
Patel, Keyur P. ;
Gonzalez, Graciela Nogueras ;
Luthra, Rajyalakshmi ;
Shamanna, Rashmi Kanagal ;
Sasaki, Koji ;
Jabbour, Elias ;
Romo, Carlos Guillermo ;
Kadia, Tapan M. ;
Pemmaraju, Naveen ;
Daver, Naval ;
Borthakur, Gautam ;
Estrov, Zeev ;
Ravandi, Farhad ;
O'Brien, Susan ;
Cortes, Jorge .
BLOOD, 2016, 127 (10) :1269-1275
[8]   Chronic myeloid leukemia patients with the e13a2 BCR-ABL fusion transcript have inferior responses to imatinib compared to patients with the e14a2 transcript [J].
Lucas, Claire M. ;
Harris, Robert J. ;
Giannoudis, Athina ;
Davies, Andrea ;
Knight, Katy ;
Watmough, Sarah J. ;
Wang, Lihui ;
Clark, Richard E. .
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2009, 94 (10) :1362-1367
[9]   Cessation of Tyrosine Kinase Inhibitors Treatment in Chronic Myeloid Leukemia Patients with Deep Molecular Response: Results of the Euro-Ski Trial [J].
Mahon, Francois-xavier ;
Richter, Johan ;
Guilhot, Joelle ;
Hjorth-Hansen, Henrik ;
Almeida, Antonio ;
Janssen, Jeroen J. W. M. ;
Mayer, Jiri ;
Porkka, Kimmo ;
Panayiotidis, Panayiotis ;
Stromberg, Ulla ;
Berger, Marc G. ;
Diamond, Joanna ;
Ehrencrona, Hans ;
Kairisto, Veli ;
Polakova, Katerina Machova ;
Mueller, Martin C. ;
Mustjoki, Satu ;
Hochhaus, Andreas ;
Pfirrmann, Markus ;
Saussele, Susanne .
BLOOD, 2016, 128 (22)
[10]   Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective, multicentre Stop Imatinib (STIM) trial [J].
Mahon, Francois-Xavier ;
Rea, Delphine ;
Guilhot, Joelle ;
Guilhot, Francois ;
Huguet, Francoise ;
Nicolini, Franck ;
Legros, Laurence ;
Charbonnier, Aude ;
Guerci, Agnes ;
Varet, Bruno ;
Etienne, Gabriel ;
Reiffers, Josy ;
Rousselot, Philippe .
LANCET ONCOLOGY, 2010, 11 (11) :1029-1035