Glucocorticoids in Alzheimer's disease - The story so far

被引：31

作者：

Aisen, PS ^{[1
]}

Pasinetti, GM ^{[1
]}

机构：

[1] Mt Sinai Med Ctr, Dept Psychiat, New York, NY 10029 USA

来源：

DRUGS & AGING | 1998年 / 12卷 / 01期

关键词：

D O I：

10.2165/00002512-199812010-00001

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The inflammatory hypothesis of Alzheimer's disease states that specific inflammatory mechanisms, including the cytokine-driven acute-phase response, complement activation and microglial activation, contribute to neurodegeneration. If the hypothesis is correct, anti-inflammatory treatment aimed at suppression of these mechanisms could slow the rate of disease progression. Towards this goal, a multicentre trial of prednisone in Alzheimer's disease is under way and pilot studies of other anti-inflammatory regimens are being conducted.

引用

页码：1 / 6

页数：6

共 59 条

[1] THE MECHANISMS OF ACTION OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS [J].

ABRAMSON, SB ;

WEISSMANN, G .

ARTHRITIS AND RHEUMATISM, 1989, 32 (01) :1-9

[2]

AISEN PS, 1994, AM J PSYCHIAT, V151, P1105

[3] A pilot study of prednisone in Alzheimer's disease [J].

Aisen, PS ;

Marin, D ;

Altstiel, L ;

Goodwin, C ;

Baruch, B ;

Jacobson, R ;

Ryan, T ;

Davis, KL .

DEMENTIA, 1996, 7 (04) :201-206

[4]

AISEN PS, 1996, ALZHEIMERS RES, V2, P153

[5] ELEVATED ALPHA(1)-ANTICHYMOTRYPSIN SERUM LEVELS IN A SUBSET OF NONDEMENTED FIRST-DEGREE RELATIVES OF ALZHEIMERS-DISEASE PATIENTS [J].

ALTSTIEL, LD ;

LAWLOR, B ;

MOHS, R ;

SCHMEIDLER, J ;

DALTON, A ;

MEHTA, P ;

DAVIS, K .

DEMENTIA, 1995, 6 (01) :17-20

[6] INTERLEUKIN-6 AND ALPHA-2-MACROGLOBULIN INDICATE AN ACUTE-PHASE STATE IN ALZHEIMERS-DISEASE CORTICES [J].

BAUER, J ;

STRAUSS, S ;

SCHREITERGASSER, U ;

GANTER, U ;

SCHLEGEL, P ;

WITT, I ;

YOLK, B ;

BERGER, M .

FEBS LETTERS, 1991, 285 (01) :111-114

[7] SEROLOGICAL ALPHA-1-ANTICHYMOTRYPSIN IN DOWNS-SYNDROME AND ALZHEIMERS-DISEASE [J].

BRUGGE, K ;

KATZMAN, R ;

HILL, LR ;

HANSEN, LA ;

SAITOH, T .

ANNALS OF NEUROLOGY, 1992, 32 (02) :193-197

[8] NEUROLOGIC DISEASE INDUCED IN TRANSGENIC MICE BY CEREBRAL OVEREXPRESSION OF INTERLEUKIN-6 [J].

CAMPBELL, IL ;

ABRAHAM, CR ;

MASLIAH, E ;

KEMPER, P ;

INGLIS, JD ;

OLDSTONE, MBA ;

MUCKE, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (21) :10061-10065

[9] INDUCTION BY LIPOPOLYSACCHARIDE OF CYCLOOXYGENASE-2 MESSENGER-RNA IN FAT BRAIN - ITS POSSIBLE ROLE IN THE FEBRILE RESPONSE [J].

CAO, CY ;

MATSUMURA, K ;

YAMAGATA, K ;

WATANABE, Y .

BRAIN RESEARCH, 1995, 697 (1-2) :187-196

[10]

Chang JW, 1996, NEUROBIOL AGING, V17, P801

← 1 2 3 4 5 6 →