Mechanism of noradrenaline-induced stimulation of Na-K ATPase activity in the rat brain: implications on REM sleep deprivation-induced increase in brain excitability

被引：14
作者：
Mallick, Birendra Nath [1 ]
Singh, Sudhuman [1 ]
Singh, Abhishek [1 ]
机构：
[1] Jawaharlal Nehru Univ, Sch Life Sci, New Delhi 110067, India
来源：
MOLECULAR AND CELLULAR BIOCHEMISTRY | 2010年 / 336卷 / 1-2期
关键词：
Adrenoceptors; Calcium; Excitability; Lipid peroxidation; Na-K ATPase; REM sleep; EYE-MOVEMENT SLEEP; LOCUS-COERULEUS NEURONS; NA; K-ATPASE BETA-SUBUNIT; P-TYPE ATPASES; NA+; K+-ATPASE ALPHA-SUBUNIT; PROTEIN-COUPLED RECEPTOR; CENTRAL-NERVOUS-SYSTEM; ADENOSINE-TRIPHOSPHATASE; SODIUM-PUMP; PARADOXICAL SLEEP;
D O I：
10.1007/s11010-009-0260-9
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Rapid eye movement (REM) sleep is a unique phenomenon expressed in all higher forms of animals. Its quantity varies in different species and with ageing; it is also affected in several psycho-somatic disorders. Several lines of studies showed that after REM sleep loss, the levels of noradrenaline (NA) increase in the brain. The NA in the brain modulates neuronal Na-K ATPase activity, which helps maintaining the brain excitability status. The detailed mechanism of increase in NA level after REM sleep loss and the effect of NA on stimulation of Na-K ATPase in the neurons have been discussed. The findings have been reviewed and discussed with an aim to understand the role of REM sleep in maintaining brain excitability status.
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收藏
页码：3 / 16
页数：14
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