Dienolether condensations -: a powerful tool in carotenoid synthesis

被引：10

作者：

Rüttimann, A ^{[1
]}

机构：

[1] F Hoffmann La Roche & Co Ltd, Chem Proc Technol Vitamins & Fine Chem Div, CH-4070 Basel, Switzerland

来源：

PURE AND APPLIED CHEMISTRY | 1999年 / 71卷 / 12期

关键词：

D O I：

10.1351/pac199971122285

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The catalytic dienolether condensation reactions, discovered by Nazarov and Makin in 1958, are of special interest in the carotenoid field for chain extension by five carbon atoms. In this paper, new developments in the synthesis of apoesters and apocarotenals using vinyl ketene acetals and dienolethers, respectively, as C-5-building blocks are discussed. New 'Wittig-free' routes to astaxanthin and canthaxanthin applying these Lewis acid-catalysed dienolether condensation reactions are described.

引用

页码：2285 / 2293

页数：9

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