Neuroprotective effects of astaxanthin in a rat model of spinal cord injury

被引:50
作者
Masoudi, Alireza [1 ]
Dargahi, Leila [2 ]
Abbaszadeh, Fatemeh [2 ]
Pourgholami, Mohammad Hosein [3 ]
Asgari, Alireza [4 ,5 ]
Manoochehri, Mehdi [6 ]
Jorjani, Masoumeh [1 ,2 ]
机构
[1] Shahid Beheshti Univ Med Sci, Sch Med, Dept Pharmacol, Tehran, Iran
[2] Shahid Beheshti Univ Med Sci, Neurobiol Res Ctr, Tehran, Iran
[3] Shahid Beheshti Univ Med Sci, Neurosci Res Ctr, Tehran, Iran
[4] Baqiyatallah Univ Med Sci, Sport Physiol Res Ctr, Tehran, Iran
[5] AJA Med Sci Univ, Aerosp Med Res Ctr, Tehran, Iran
[6] Shahroud Univ Med Sci, Sch Med, Shahroud, Iran
关键词
Astaxanthin; Neuroprotection; Spinal cord injury; Apoptosis; EARLY BRAIN-INJURY; OXIDATIVE STRESS; FUNCTIONAL RECOVERY; TRAUMATIC BRAIN; SUBARACHNOID HEMORRHAGE; ELECTROLYTIC LESION; SPINOTHALAMIC TRACT; CEREBRAL-ISCHEMIA; IN-VITRO; APOPTOSIS;
D O I
10.1016/j.bbr.2017.04.026
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Spinal cord injury (SCI) often leads to constant neurological deficits and long-term unalterable disability. Apoptosis plays an important role in the initiation of the secondary injury cascades leading to progressive tissue damage and severely functional deficits after SCI. Although the primary mechanical destructive events cannot be reversed, a therapeutic intervention could be carried out in order to moderate the secondary injury damage several hours to weeks after injury. Astaxanthin (AST) is a strong antioxidant and anti-inflammatory agents with the potential to render anti-apoptotic and neuroprotective effects. In the current study, we examined the therapeutic potential of AST on adult rats after severe SCI contusion. Results of BBB scores showed that AST improved motor function after SCI compared to control groups. Westem blot analysis showed reduced expression of Box and Cleaved-caspase-3 proteins and increased expression of the Bcl-2 protein in response to AST treatment (p < 0.05). The histology results also showed that AST considerably preserved myelinated white matter and the number of motor neurons. This study is the first to report that AST reduces neuronal apoptosis, diminishes pathological tissue damage and improves functional recovery after SCI. The observed prominent neuroprotective effects, introduces AST as a promising therapy for SCI.
引用
收藏
页码:104 / 110
页数:7
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