Neuroprotective effects of astaxanthin in a rat model of spinal cord injury
被引:50
作者:
论文数: 引用数:
h-index:
机构:
Masoudi, Alireza
[1
]
Dargahi, Leila
论文数: 0引用数: 0
h-index: 0
机构:
Shahid Beheshti Univ Med Sci, Neurobiol Res Ctr, Tehran, IranShahid Beheshti Univ Med Sci, Sch Med, Dept Pharmacol, Tehran, Iran
Dargahi, Leila
[2
]
论文数: 引用数:
h-index:
机构:
Abbaszadeh, Fatemeh
[2
]
Pourgholami, Mohammad Hosein
论文数: 0引用数: 0
h-index: 0
机构:
Shahid Beheshti Univ Med Sci, Neurosci Res Ctr, Tehran, IranShahid Beheshti Univ Med Sci, Sch Med, Dept Pharmacol, Tehran, Iran
Pourgholami, Mohammad Hosein
[3
]
Asgari, Alireza
论文数: 0引用数: 0
h-index: 0
机构:
Baqiyatallah Univ Med Sci, Sport Physiol Res Ctr, Tehran, Iran
AJA Med Sci Univ, Aerosp Med Res Ctr, Tehran, IranShahid Beheshti Univ Med Sci, Sch Med, Dept Pharmacol, Tehran, Iran
Asgari, Alireza
[4
,5
]
Manoochehri, Mehdi
论文数: 0引用数: 0
h-index: 0
机构:
Shahroud Univ Med Sci, Sch Med, Shahroud, IranShahid Beheshti Univ Med Sci, Sch Med, Dept Pharmacol, Tehran, Iran
Spinal cord injury (SCI) often leads to constant neurological deficits and long-term unalterable disability. Apoptosis plays an important role in the initiation of the secondary injury cascades leading to progressive tissue damage and severely functional deficits after SCI. Although the primary mechanical destructive events cannot be reversed, a therapeutic intervention could be carried out in order to moderate the secondary injury damage several hours to weeks after injury. Astaxanthin (AST) is a strong antioxidant and anti-inflammatory agents with the potential to render anti-apoptotic and neuroprotective effects. In the current study, we examined the therapeutic potential of AST on adult rats after severe SCI contusion. Results of BBB scores showed that AST improved motor function after SCI compared to control groups. Westem blot analysis showed reduced expression of Box and Cleaved-caspase-3 proteins and increased expression of the Bcl-2 protein in response to AST treatment (p < 0.05). The histology results also showed that AST considerably preserved myelinated white matter and the number of motor neurons. This study is the first to report that AST reduces neuronal apoptosis, diminishes pathological tissue damage and improves functional recovery after SCI. The observed prominent neuroprotective effects, introduces AST as a promising therapy for SCI.
机构:
New York Med Coll, Dept Neurosurg, Valhalla, NY 10595 USANew York Med Coll, Dept Neurosurg, Valhalla, NY 10595 USA
Ormond, D. Ryan
;
Peng, Hong
论文数: 0引用数: 0
h-index: 0
机构:
New York Med Coll, Dept Cell Biol & Anat, Valhalla, NY 10595 USANew York Med Coll, Dept Neurosurg, Valhalla, NY 10595 USA
Peng, Hong
;
Zeman, Richard
论文数: 0引用数: 0
h-index: 0
机构:
New York Med Coll, Dept Cell Biol & Anat, Valhalla, NY 10595 USANew York Med Coll, Dept Neurosurg, Valhalla, NY 10595 USA
Zeman, Richard
;
Das, Kaushik
论文数: 0引用数: 0
h-index: 0
机构:
New York Med Coll, Dept Neurosurg, Valhalla, NY 10595 USANew York Med Coll, Dept Neurosurg, Valhalla, NY 10595 USA
Das, Kaushik
;
Murali, Raj
论文数: 0引用数: 0
h-index: 0
机构:
New York Med Coll, Dept Neurosurg, Valhalla, NY 10595 USANew York Med Coll, Dept Neurosurg, Valhalla, NY 10595 USA
Murali, Raj
;
Jhanwar-Uniyal, Meena
论文数: 0引用数: 0
h-index: 0
机构:
New York Med Coll, Dept Neurosurg, Valhalla, NY 10595 USA
New York Med Coll, Dept Pathol, Valhalla, NY 10595 USANew York Med Coll, Dept Neurosurg, Valhalla, NY 10595 USA
机构:
New York Med Coll, Dept Neurosurg, Valhalla, NY 10595 USANew York Med Coll, Dept Neurosurg, Valhalla, NY 10595 USA
Ormond, D. Ryan
;
Peng, Hong
论文数: 0引用数: 0
h-index: 0
机构:
New York Med Coll, Dept Cell Biol & Anat, Valhalla, NY 10595 USANew York Med Coll, Dept Neurosurg, Valhalla, NY 10595 USA
Peng, Hong
;
Zeman, Richard
论文数: 0引用数: 0
h-index: 0
机构:
New York Med Coll, Dept Cell Biol & Anat, Valhalla, NY 10595 USANew York Med Coll, Dept Neurosurg, Valhalla, NY 10595 USA
Zeman, Richard
;
Das, Kaushik
论文数: 0引用数: 0
h-index: 0
机构:
New York Med Coll, Dept Neurosurg, Valhalla, NY 10595 USANew York Med Coll, Dept Neurosurg, Valhalla, NY 10595 USA
Das, Kaushik
;
Murali, Raj
论文数: 0引用数: 0
h-index: 0
机构:
New York Med Coll, Dept Neurosurg, Valhalla, NY 10595 USANew York Med Coll, Dept Neurosurg, Valhalla, NY 10595 USA
Murali, Raj
;
Jhanwar-Uniyal, Meena
论文数: 0引用数: 0
h-index: 0
机构:
New York Med Coll, Dept Neurosurg, Valhalla, NY 10595 USA
New York Med Coll, Dept Pathol, Valhalla, NY 10595 USANew York Med Coll, Dept Neurosurg, Valhalla, NY 10595 USA