Traditional Chinese medicine extraction method by ethanol delivers drug-like molecules

被引：16
作者：
Miao, William G. [1 ]
Tang, Chunping [2 ]
Ye, Yang [2 ]
Quinn, Ronald J. [1 ]
Feng, Yunjiang [1 ]
机构：
[1] Griffith Univ, Griffith Inst Drug Discovery GRIDD, Nathan, Qld 4111, Australia
[2] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
来源：
CHINESE JOURNAL OF NATURAL MEDICINES | 2019年 / 17卷 / 09期
关键词：
Extraction; Traditional Chinese medicine (TCM); Natural products; Lipinski's Ro5Physicochemical properties; PHENOLIC-COMPOUNDS; HERBAL MEDICINES; GASTRODIA-ELATA; CONSTITUENTS; DISCOVERY; INHIBITION; PRINCIPLES; RHIZOMES;
D O I：
10.1016/S1875-5364(19)30086-X
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
Traditional Chinese Medicine (TCM) is an important reservoir for bioactive natural products. TCM extraction methods by water decoction and wine tincture are an integral part of TCM and essential for their widely acknowledged efficacy. In this study, we selected 6 common TCMs that are rich in chemistry to investigate whether the TCM extraction methods deliver molecules with drug-like physical chemical properties. Six TCM herbal materials were extracted by water, 95% ethanol, and sequential hexane, dichloromethane and methanol. The extracts were analyzed by HPLC and H-1 NMR. Isolation on one of the extracts yielded 32 compounds, their physical chemical properties were analyzed by Instant JChem. Our results showed that ethanol extraction, which mimics TCM wine tincture, delivered compounds with physical chemical properties compliant to Lipinski's rule of 5.
引用
收藏
页码：713 / 720
页数：8
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