Physical Activity Modulates Common Neuroplasticity Substrates in Major Depressive and Bipolar Disorder

被引:21
作者
Phillips, Cristy [1 ]
机构
[1] A State, Dept Phys Therapy, Jonesboro, AR 72401 USA
关键词
LEUKOCYTE TELOMERE LENGTH; CEREBRAL-BLOOD-FLOW; QUALITY-OF-LIFE; GLUCOCORTICOID-RECEPTOR EXPRESSION; ADULT HIPPOCAMPAL NEUROGENESIS; FACTOR VAL66MET POLYMORPHISM; MILD COGNITIVE IMPAIRMENT; BRIGHT-LIGHT EXPOSURE; ADD-ON TREATMENT; NEUROTROPHIC FACTOR;
D O I
10.1155/2017/7014146
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Mood disorders(MDs) are chronic, recurrent mental diseases that affect millions of individuals worldwide. Although the biogenic amine model has provided some clinical utility, a need remains to better understand the interrelated mechanisms that contribute to neuroplasticity deficits in MDs and the means by which various therapeutics mitigate them. Of those therapeutics being investigated, physical activity (PA) has shown clear and consistent promise. Accordingly, the aims of this review are to (1) explicate key modulators, processes, and interactions that impinge upon multiple susceptibility points to effectuate neuroplasticity deficits in MDs; (2) explore the putative mechanisms by which PA mitigates these features; (3) review protocols used to induce the positive effects of PA in MDs; and (4) highlight implications for clinicians and researchers.
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页数:37
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