Achieving conformational control over C-C, C-N and C-O bonds in biaryls, N,N′-diarylureas and diaryl ethers:: advantages of a relay axis

被引：23

作者：

Betson, Mark S. ^{[1
]}

Bracegirdle, Ann ^{[1
]}

Clayden, Jonathan ^{[1
]}

Helliwell, Madeleine ^{[1
]}

Lund, Andrew ^{[1
]}

Pickworth, Mark ^{[1
]}

Snape, Timothy J. ^{[1
]}

Worrall, Christopher P. ^{[1
]}

机构：

[1] Univ Manchester, Sch Chem, Manchester M13 9PL, Lancs, England

来源：

CHEMICAL COMMUNICATIONS | 2007年 / 07期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1039/b614618j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The orientation of Ar-C, Ar-N and Ar-O bonds in biaryls, N,N'-diarylureas and diaryl ethers (whose conformers are distinguishable by NMR) may be controlled with a selectivity up to > 95 : 5 by an adjacent stereogenic centre; the selectivity may be greater when a second stereogenic axis is inserted between the controlling centre and the slowly rotating bond.

引用

页码：754 / 756

页数：3

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