Clinical implications of riociguat pharmacokinetics and pharmacodynamics: introduction to the riociguat clinical pharmacology supplement

被引：3
作者：
Frey, Reiner [1 ]
Mueck, Wolfgang [1 ]
机构：
[1] Bayer Pharma, Pharma Res Ctr, Clin Pharmacol, Wuppertal, Germany
来源：
PULMONARY CIRCULATION | 2016年 / 6卷
关键词：
SOLUBLE GUANYLATE-CYCLASE; PULMONARY ARTERIAL-HYPERTENSION; LONG-TERM EXTENSION; BAY; 63-2521; STIMULATOR RIOCIGUAT; POPULATION PHARMACOKINETICS; HEPATIC IMPAIRMENT; BIOAVAILABILITY; ABSORPTION; SMOKING;
D O I：
10.1086/685821
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：S1 / S4
页数：4
相关论文
共 29 条
[1]  
[Anonymous], Annex I summary of Product Characteristics, Namuscla.
[2]  
Bayer HealthCare Pharmaceuticals, PRESCR INF AD RIOC T
[3]   Effects of omeprazole and aluminum hydroxide/magnesium hydroxide on riociguat absorption [J].
Becker, Corina ;
Frey, Reiner ;
Unger, Sigrun ;
Artmeier-Brandt, Ulrike ;
Weimann, Gerrit ;
Mueck, Wolfgang .
PULMONARY CIRCULATION, 2016, 6 :S43-S48
[4]   Pharmacokinetic interaction of riociguat with ketoconazole, clarithromycin, and midazolam [J].
Becker, Corina ;
Frey, Reiner ;
Unger, Sigrun ;
Thomas, Dirk ;
Reber, Michael ;
Weimann, Gerrit ;
Dietrich, Hartmut ;
Arens, Erich R. ;
Mueck, Wolfgang .
PULMONARY CIRCULATION, 2016, 6 :S49-S57
[5]   Absorption of riociguat (BAY 63-2521): bioavailability, food effects, and dose proportionality [J].
Becker, Corina ;
Frey, Reiner ;
Hesse, Christiane ;
Unger, Sigrun ;
Reber, Michael ;
Mueck, Wolfgang .
PULMONARY CIRCULATION, 2016, 6 :S27-S34
[6]   Tobacco smoke-dependent changes in cytochrome P450 1A1, 1A2, and 2E1 protein expressions in fetuses, newborns, pregnant rats, and human placenta [J].
Czekaj, P ;
Wiaderkiewicz, A ;
Florek, E ;
Wiaderkiewicz, R .
ARCHIVES OF TOXICOLOGY, 2005, 79 (01) :13-24
[7]   Single-dose pharmacokinetics, pharmacodynamics, tolerability, and safety of the soluble guanylate cyclase stimulator BAY 63-2521:: An ascending-dose study in healthy male volunteers [J].
Frey, Reiner ;
Mueck, Wolfgang ;
Unger, Sigrun ;
Artmeier-Brandt, Ulrike ;
Weimann, Gerrit ;
Wensing, Georg .
JOURNAL OF CLINICAL PHARMACOLOGY, 2008, 48 (08) :926-934
[8]   Pharmacokinetic interaction study between riociguat and the combined oral contraceptives levonorgestrel and ethinylestradiol in healthy postmenopausal women [J].
Frey, Reiner ;
Unger, Sigrun ;
van der Mey, Dorina ;
Becker, Corina ;
Saleh, Soundos ;
Wensing, Georg ;
Mueck, Wolfgang .
PULMONARY CIRCULATION, 2016, 6 :S97-S102
[9]   Effects of age and sex on the pharmacokinetics of the soluble guanylate cyclase stimulator riociguat (BAY 63-2521) [J].
Frey, Reiner ;
Saleh, Soundos ;
Becker, Corina ;
Mueck, Wolfgang .
PULMONARY CIRCULATION, 2016, 6 :S58-S65
[10]   Riociguat (BAY 63-2521) and aspirin: a randomized, pharmacodynamic, and pharmacokinetic interaction study [J].
Frey, Reiner ;
Reber, Michael ;
Kraetzschmar, Joern ;
Unger, Sigrun ;
Mueck, Wolfgang ;
Wensing, Georg .
PULMONARY CIRCULATION, 2016, 6 :S35-S42
123