Effects of a Structured Exercise Program on Physical Activity and Fitness in Colon Cancer Survivors: One Year Feasibility Results from the CHALLENGE Trial

被引：76

作者：

Courneya, Kerry S. ^{[1
]}

Vardy, Janette L. ^{[2
]}

O'Callaghan, Christopher J. ^{[3
]}

Friedenreich, Christine M. ^{[4
]}

Campbell, Kristin L. ^{[5
]}

Prapavessis, Harry ^{[6
]}

Crawford, Jennifer J. ^{[1
]}

O'Brien, Patti ^{[3
]}

Dhillon, Haryana M. ^{[2
]}

Jonker, Derek J. ^{[7
]}

Chua, Neil S. ^{[8
]}

Lupichuk, Sasha ^{[9
]}

Sanatani, Michael S. ^{[10
]}

Gill, Sharlene ^{[11
]}

Meyer, Ralph M. ^{[12
,13
]}

Begbie, Stephen ^{[14
]}

Bonaventura, Tony ^{[15
]}

Burge, Matthew E. ^{[16
]}

Turner, Jane ^{[2
]}

Tu, Dongsheng ^{[3
]}

Booth, Christopher M. ^{[17
]}

机构：

[1] Univ Alberta, Edmonton, AB, Canada

[2] Univ Sydney, Sydney, NSW 2006, Australia

[3] Canadian Canc Trials Grp, Kingston, ON, Canada

[4] Alberta Hlth Serv, Calgary, AB, Canada

[5] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada

[6] Univ Western Ontario, London, ON, Canada

[7] Ottawa Hosp, Res Inst, Ottawa, ON, Canada

[8] Cross Canc Inst, Edmonton, AB T6G 1Z2, Canada

[9] Tom Baker Canc Clin, Calgary, AB, Canada

[10] London Reg Canc Ctr, 790 Commissioners Rd E, London, ON N6A 4L6, Canada

[11] British Columbia Canc Agcy, Vancouver, BC V5Z 4E6, Canada

[12] Juravinski Hosp & Canc Ctr, Hamilton, ON, Canada

[13] McMaster Univ, Hamilton, ON, Canada

[14] North Coast Canc Inst, Coffs Harbour, NSW, Australia

[15] Newcastle Private Hosp, Newcastle, NSW, Australia

[16] Royal Brisbane & Womens Hosp, Herston, Qld, Australia

[17] Queens Univ, Kingston, ON, Canada

来源：

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | 2016年 / 25卷 / 06期

基金：

英国医学研究理事会;

关键词：

BEHAVIOR-CHANGE INTERVENTIONS; RANDOMIZED CONTROLLED-TRIAL; WEIGHT-LOSS INTERVENTION; POPULATION-BASED SAMPLE; LONG-TERM MAINTENANCE; MINUTE WALK TEST; QUALITY-OF-LIFE; COLORECTAL-CANCER; BREAST-CANCER; PLANNED BEHAVIOR;

D O I：

10.1158/1055-9965.EPI-15-1267

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: There is strong interest in testing lifestyle interventions to improve cancer outcomes; however, the optimal methods for achieving behavior change in large-scale pragmatic trials are unknown. Here, wereport the 1-year feasibility results for exercise behavior change in the Canadian Cancer Trials Group CO. 21 (CHALLENGE) Trial. Methods: Between 2009 and 2014, 273 high-risk stage II and III colon cancer survivors from 42 centers in Canada and Australia were randomized to a structured exercise program (SEP; n = 136) or health education materials (HEM; n = 137). The primary feasibility outcome in a prespecified interim analysis was a difference between randomized groups of >= 5 metabolic equivalent task (MET)-hours/week in self-reported recreational physical activity (PA) after at least 250 participants reached the 1-year follow-up. Secondary outcomes included health-related fitness. Results: The SEP group reported an increase in recreational PAof 15.6 MET-hours/week compared with 5.1 MET-hours/week in the HEM group [mean difference = +10.5; 95% confidence interval (CI) = _+3.1-+17.9; P = 0.002]. The SEP group also improved relative to the HEM group in predicted VO2max (P = 0.068), 6-minute walk (P < 0.001), 30-second chair stand (P < 0.001), 8-foot up-and-go (P = 0.004), and sit-and-reach (P = 0.08). Conclusions: The behavior change intervention in the CHALLENGE Trial produced a substantial increase in selfreported recreational PA that met the feasibility criterion for trial continuation, resulted in objective fitness improvements, and is consistent with the amount of PA associated with improved colon cancer outcomes in observational studies. Impact: The CHALLENGE Trial is poised to determine the causal effects of PA on colon cancer outcomes. (C) 2016 AACR.

引用

页码：969 / 977

页数：9

共 51 条

[1] Compendium of Physical Activities: an update of activity codes and MET intensities [J].