Body builder: from synthetic cells to engineered tissues

被引：15

作者：

Hu, Shiqi ^{[1
,2
,3
]}

Ogle, Brenda M. ^{[4
]}

Cheng, Ke ^{[1
,2
,3
]}

机构：

[1] NC State Univ, Comparat Med Inst, Dept Mol Biomed Sci, Raleigh, NC 27607 USA

[2] Univ N Carolina, Joint Dept Biomed Engn & Comparat Med Inst, Raleigh, NC 27607 USA

[3] NC State Univ, Raleigh, NC 27607 USA

[4] Univ Minnesota, Dept Biomed Engn, Stem Cell Inst, Masonic Canc Ctr, Minneapolis, MN 55455 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2018年 / 54卷

关键词：

ACUTE MYOCARDIAL-INFARCTION; STEM-CELLS; CARDIAC REGENERATION; HEART; THERAPY; FABRICATION; MICE;

D O I：

10.1016/j.ceb.2018.04.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

It is estimated that 18 Americans die every day waiting for an organ donation. And even if a patient receives the organ that s/he needs, there is still >10% chance that the new organ will not work. The field of tissue engineering and regenerative medicine aims to actively use a patient's own cells, plus biomaterials and factors, to grow specific tissues for replacement or to restore normal functions of that organ, which would eliminate the need for donors and the risk of alloimmune rejection. In this review, we summarized recent advances in fabricating synthetic cells, with a specific focus on their application to cardiac regenerative medicine and tissue engineering. At the end, we pointed to challenges and future directions for the field.

引用

页码：37 / 42

页数：6

共 33 条

[1] A futile cycle in cell therapy [J].

不详 .

NATURE BIOTECHNOLOGY, 2017, 35 (04) :291-291

[2] RETRACTED: Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial (Retracted article. See vol. 393, pg. 1084, 2019) [J].

Bolli, Roberto ;

Chugh, Atul R. ;

D'Amario, Domenico ;

Loughran, John H. ;

Stoddard, Marcus F. ;

Ikram, Sohail ;

Beache, Garth M. ;

Wagner, Stephen G. ;

Leri, Annarosa ;

Hosoda, Toru ;

Sanada, Fumihiro ;

Elmore, Julius B. ;

Goichberg, Polina ;

Cappetta, Donato ;

Solankhi, Naresh K. ;

Fahsah, Ibrahim ;

Rokosh, D. Gregg ;

Slaughter, Mark S. ;

Kajstura, Jan ;

Anversa, Piero .

LANCET, 2011, 378 (9806) :1847-1857

[3] From Microscale Devices to 3D Printing Advances in Fabrication of 3D Cardiovascular Tissues [J].

Borovjagin, Anton V. ;

Ogle, Brenda M. ;

Berry, Joel L. ;

Zhang, Jianyi .

CIRCULATION RESEARCH, 2017, 120 (01) :150-165

[4] SEMIPERMEABLE MICROCAPSULES [J].

CHANG, TMS .

SCIENCE, 1964, 146 (364) :524-&

[5] Human embryonic-stem-cell-derived cardiomyocytesregenerate non-humanprimate hearts [J].

Chong, James J. H. ;

Yang, Xiulan ;

Don, Creighton W. ;

Minami, Elina ;

Liu, Yen-Wen ;

Weyers, Jill J. ;

Mahoney, William M., Jr. ;

Van Biber, Benjamin ;

Cook, Savannah M. ;

Palpant, Nathan J. ;

Gantz, Jay A. ;

Fugate, James A. ;

Muskheli, Veronica ;

Gough, G. Michael ;

Vogel, Keith W. ;

Astley, Cliff A. ;

Hotchkiss, Charlotte E. ;

Baldessari, Audrey ;

Pabon, Lil ;

Reinecke, Hans ;

Gill, Edward A. ;

Nelson, Veronica ;

Kiem, Hans-Peter ;

Laflamme, Michael A. ;

Murry, Charles E. .

NATURE, 2014, 510 (7504) :273-+

[6] Role of integrins in mediating cardiac fibroblast-cardiomyocyte cross talk: a dynamic relationship in cardiac biology and pathophysiology [J].

Civitarese, Robert A. ;

Kapus, Andras ;

McCulloch, Christopher A. ;

Connelly, Kim A. .

BASIC RESEARCH IN CARDIOLOGY, 2017, 112 (01)

[7] Lancet Commission: Stem cells and regenerative medicine [J].

Cossu, Giulio ;

Birchall, Martin ;

Brown, Tracey ;

De Coppi, Paolo ;

Culme-Seymour, Emily ;

Gibbon, Sahra ;

Hitchcock, Julian ;

Mason, Chris ;

Montgomery, Jonathan ;

Morris, Steve ;

Muntoni, Francesco ;

Napier, David ;

Owji, Nazanin ;

Prasad, Aarathi ;

Round, Jeff ;

Saprai, Prince ;

Stilgoe, Jack ;

Thrasher, Adrian ;

Wilson, James .

LANCET, 2018, 391 (10123) :883-910

[8] Challenges in identifying the best source of stem cells for cardiac regeneration therapy [J].

Dixit, Parul ;

Katare, Rajesh .

STEM CELL RESEARCH & THERAPY, 2015, 6

[9] Stem Cell Technology in Cardiac Regeneration: A Pluripotent Stem Cell Promise [J].

Duelen, Robin ;

Sampaolesi, Maurilio .

EBIOMEDICINE, 2017, 16 :30-40

[10] Cardiomyocyte Regeneration A Consensus Statement [J].

Eschenhagen, Thomas ;

Bolli, Roberto ;

Braun, Thomas ;

Field, Loren J. ;

Fleischmann, Bernd K. ;

Frisen, Jonas ;

Giacca, Mauro ;

Hare, Joshua M. ;

Houser, Steven ;

Lee, Richard T. ;

Marbn, Eduardo ;

Martin, James F. ;

Molkentin, Jeffery D. ;

Murry, Charles E. ;

Riley, Paul R. ;

Ruiz-Lozano, Pilar ;

Sadek, Hesham A. ;

Sussman, Mark A. ;

Hill, Joseph A. .

CIRCULATION, 2017, 136 (07) :680-686

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