Perylene-Diimide-Based Nanoparticles as Highly Efficient Photoacoustic Agents for Deep Brain Tumor Imaging in Living Mice

被引：240

作者：

Fan, Quli ^{[1
,2
,3
,4
]}

Cheng, Kai ^{[3
,4
]}

Yang, Zhen ^{[1
,2
]}

Zhang, Ruiping ^{[3
,4
,5
]}

Yang, Min ^{[3
,4
,6
]}

Hu, Xiang ^{[3
,4
]}

Ma, Xiaowei ^{[3
,4
]}

Bu, Lihong ^{[3
,4
]}

Lu, Xiaomei ^{[1
,2
]}

Xiong, Xiaoxing ^{[7
]}

Huang, Wei ^{[1
,2
]}

Zhao, Heng ^{[7
]}

Cheng, Zhen ^{[3
,4
]}

机构：

[1] Nanjing Univ Posts & Telecommun, Key Lab Organ Elect & Informat Displays, Nanjing 210046, Jiangsu, Peoples R China

[2] Nanjing Univ Posts & Telecommun, Inst Adv Mat, Nanjing 210046, Jiangsu, Peoples R China

[3] Stanford Univ, Dept Radiol, MIPS, Canary Ctr Stanford Canc Early Detect, Stanford, CA 94305 USA

[4] Stanford Univ, Sch Med, BioX Program, Stanford, CA 94305 USA

[5] Shanxi Med Univ, Hosp 1, Dept Radiol, Taiyuan 030001, Peoples R China

[6] Jiangsu Inst Nucl Med, Jiangsu Key Lab Mol Nucl Med, Minist Hlth, Key Lab Nucl Med, Wuxi 214063, Peoples R China

[7] Stanford Univ, Sch Med, Dept Neurosurg, Stanford, CA 94305 USA

来源：

ADVANCED MATERIALS | 2015年 / 27卷 / 05期

基金：

中国国家自然科学基金;

关键词：

brain tumor; deep tumor imaging; near-infrared-absorption; Perylene-3; 4; 9; 10-tetracarboxylic diimide nanoparticles; photoacoustic imaging; HOLLOW GOLD NANOSPHERES; IN-VIVO; CONTRAST AGENT; POLYMER NANOPARTICLES; TOMOGRAPHY; NANOCAGES; THERAPY; MODEL;

D O I：

10.1002/adma.201402972

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In order to promote preclinical and clinical applications of photoacoustic imaging, novel photoacoustic contrast agents are highly desired for molecular imaging of diseases, especially for deep tumor imaging. Here, perylene-3,4,9,10-tetracarboxylic diiimide-based near-infrared-absorptive organic nanoparticles are reported as an efficient agent for photoacoustic imaging of deep brain tumors in living mice with enhanced permeability and retention effect.

引用

页码：843 / 847

页数：5

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