Synthesis, bioevaluation and molecular docking study of new piperazine and amide linked dimeric 1,2,3-triazoles

被引:21
作者
Deshmukh, Tejshri R. [1 ]
Khare, Smita P. [1 ]
Krishna, Vagolu S. [2 ]
Sriram, Dharmarajan [2 ]
Sangshetti, Jaiprakash N. [3 ]
Khedkar, Vijay M. [4 ]
Shingate, Bapurao B. [1 ]
机构
[1] Dr Babasaheb Ambedkar Marathwada Univ, Dept Chem, Aurangabad 431004, Maharashtra, India
[2] Birla Inst Technol & Sci Pilani, Dept Pharm, Hyderabad, Telangana, India
[3] YB Chavan Coll Pharm, Dept Pharmaceut Chem, Aurangabad, Maharashtra, India
[4] Shri Vile Parle Kelavani Mandals Inst Pharm, Dept Pharmaceut Chem, Dhule, Maharashtra, India
关键词
Antifungal activity; antioxidant activity; antitubercular activity; dimeric; 1; 2; 3-triazoles; molecular docking study; ANTITUBERCULAR AGENTS SYNTHESIS; CLICK CHEMISTRY; TRIAZOLE DERIVATIVES; FACILE SYNTHESIS; BIOLOGICAL EVALUATION; DRUG DISCOVERY; ANTIOXIDANT; CYCLOADDITION; EPIDEMIOLOGY; INHIBITORS;
D O I
10.1080/00397911.2019.1695275
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
In search of more potent new antitubercular agents, a library of novel piperazine tethered dimeric 1,2,3-triazoles were designed by assembling 1,2,3-triazoles and piperazine in a single molecular architectural framework. The titled compounds (3a-m) were synthesized by 1,3-dipolar cycloaddition of 1,4-di(prop-2-yn-1-yl)piperazine (1) and various azides (2a-m) using click chemistry approach with good yields. All the synthesized compounds (3a-m) have been screened for their in vitro antitubercular, antifungal and antioxidant activities against their respective strains. Among them, 3b, 3d, and 3i have revealed promising antitubercular activity against Mycobacterium tuberculosis (Mtb) H37Rv with MIC 12.5 mu g/mL. Molecular docking results provided well-clustered solutions to the mode of binding for these molecules into the active site of Mtb enoyl reductase (InhA). In addition to this, most of synthesized compounds were found to have potential antifungal as well as antioxidant activity.
引用
收藏
页码:271 / 288
页数:18
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